Parameter (unit) | Description | Generic values b | Spleen (s) | Liver (l) | Lungs (lu) | Heart (h) | Kidneys (k) | GI tract (gi) | Brain (br) | Rest of the body (rest) | Blood (blood) |
---|---|---|---|---|---|---|---|---|---|---|---|
W t /WB (unitless) b | % of organ weight to body weight | - | 0.0031 | 0.0396 | 0.0047 | 0.0034 | 0.0094 | 0.044 | 0.0053 | 0.84 | 0.0498 |
W t,b /W t (unitless) c | % of capillary blood in organ to organ weight | - | 0.225 | 0.156 | 0.1 | 0.175 | 0.316 | 0.1 | 0.07 | 0.017 | - |
frQ t (unitless) d | Fraction of cardiac output to organ | - | 0.0146 | 0.0465 | 1 | 0.051 | 0.141 | 0.213 | 0.02 | 0.514 | 1 |
N t (# per g) d | Phagocytizing cells number per organ weight | - | 2.08 × 108 | 2.72 × 107 | 2.69 × 106, 3.90 × 10 6 ± 3.71 × 10 2 g | 7.60 × 104 | 9.90 × 104 | 5.06 × 10 5 ± 2.22 × 10 3 | 3.06 × 105 | 8.11 × 106 | 1.85 × 103 |
M cap (μg per #) f | Maximum uptake capacity in individual phagocytizing cells | 5.52 × 10 −7 ± 6.98 × 10 −11 | - | - | - | - | - | - | - | - | - |
χ α (unitless) f | Permeability coefficient between blood and tissue | 7.76 × 10 −1 ± 2.14 × 10 −4 | Generic | Generic | Generic | Generic | Generic | Generic | 6.75 × 10 −7 ± 8.84 × 10 −11 | 1.71 × 10 −2 ± 6.54 × 10 −7 | - |
P (unitless) f | Partition coefficient between tissue and blood | 2.09 × 10 −1 ± 9.83 × 10 −7 | Generic | Generic | Generic | Generic | Generic | Generic | Generic | Generic | 1 |
k ab0 (per h) f | Maximum uptake rate by phagocytizing cells | 1.45 × 10 0 ± 4.62 × 10 −5 | 5.18 × 10 −1 ± 5.87 × 10 −5 | Generic | Generic | Generic | Generic | Generic | Generic | Generic | Generic |
k de (per h) f | Desorption rate by phagocytizing cells | 5.30 × 10 −19 ± 1.24 × 10 −17 | Generic | Generic | Generic | Generic | Generic | Generic | Generic | Generic | Generic |
CLE e (per h) | Clearance rate to excreta | - | - | 1.52 × 10 −3 ± 6.97 × 10 −6 | - | - | 3.26 × 10 0 ± 2.70 × 10 −3 | 1.41 × 10 −1 ± 8.42 × 10 −7 | - | - | - |
fr β (unitless) e, f | Fraction of capillary blood of organs left when analyzed | 0.144 | Generic | Generic | Generic | Generic | Generic | Generic | 0.371 | Generic | - |