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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

Fig. 5

Effect of metal NPs and hyaluronan oligomers on the elastic fiber formation in the ECM. Initially, the tropoelastin molecule is secreted from the cell and binds to the elastin binding protein (EBP) on the cell membrane. Tropoelastin deposition and crosslinking by LOX on the glycoprotein microfibrils form mature tropoelastin fibers. (ROS: reactive oxygen species, MMP: matrix metalloproteinase, TIMP: tissue inhibitors of matrix proteases, IL-1beta: interleukin-1beta, TGF-beta: transforming growth factor beta, BMP-1: Bone morphogenetic protein-1/Tolloid metalloproteinase, PI3Kinase: Phosphoinositide 3-kinase, LOX: Lysyl oxidase)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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