Histopathological findings (♀) | Incidence | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lung | day 1 | day 28 | day 90Â +Â 1rec | day 90Â +Â 28rec | day 90Â +Â 90rec | |||||||||||
Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | ||
Accumulation, particle-laden macrophages, alveolar/interstitial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 10 | 10 | 0 | 10 | 10 | 0 | 10 | 10 | 0 | 1 | 5 | 0 | 1 | 9 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 9 | 1 | |
Accumulation, particle-laden macrophages, BALT | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 5 | 5 | 0 | 10 | 8 | 0 | 6 | 8 | 0 | 5 | 6 | 0 | 6 | 3 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3 | 0 | 0 | 3 | 0 | |
moderate | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | |
Hyperplasia, bronchiolo-alveolar | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4 | 2 | 0 | 7 | 1 | 0 | 5 | 1 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
Infiltration of inflammatory cells, alveolar/interstitial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6 | 5 | 0 | 5 | 5 | 0 | 5 | 3 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 5 | 0 | 0 | 5 | 0 | |
Particles, alveolar | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 10 | 0 | 10 | 5 | 0 | 10 | 0 | |
Giant cells, syncytial, BALT | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
present, no grade | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 0 | 0 | 2 | 0 | |
Fibrosis, interstitial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 3 | 1 | 0 | 7 | 0 | |
Lung-associated lymph nodes | day 1 | day 28 | day 90Â +Â 1rec | day 90Â +Â 28rec | day 90Â +Â 90rec | |||||||||||
Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | ||
Accumulation, particle-laden macrophages, mediastinal lnn. | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 7 | 10 | 0 | 2 | 7 | 0 | 0 | 6 | 0 | 0 | 5 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 2 | 1 | 0 | 0 | 4 | |
moderate | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 8 | 0 | 0 | 9 | 0 | |
severe | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
Accumulation, particle-laden macrophages, tracheobronchial lnn. | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 10 | 10 | 0 | 0 | 8 | 0 | 0 | 4 | 0 | 0 | 4 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 5 | 0 | 0 | 6 | |
moderate | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 8 | 1 | 0 | 10 | 0 | |
severe | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
Giant cells, syncytial, mediastinal lnn. | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
present, no grade | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 7 | 0 | 0 | 10 | 0 | |
Giant cells, syncytial, tracheobronchial lnn. | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
present, no grade | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 8 | 0 | 0 | 10 | 0 | |
Nasal cavity | day 1 | day 28 | day 90Â +Â 1rec | day 90Â +Â 28rec | day 90Â +Â 90rec | |||||||||||
Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | Ctrl. | CeO2 | BaSO4 | ||
Accumulation of particle-laden macrophages, NALT | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 5 | 8 | 0 | 10 | 4 | 0 | 6 | 0 | 0 | 10 | 0 | |
Globules, eosinophilic, olfactory epithelial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 2 | 3 | 2 | 3 | 8 | 1 | 2 | 4 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 1 | 0 | 0 | 3 | |
Globules, eosinophilic, respiratory epithelial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 3 | 0 | 1 | 9 | 2 | 2 | 9 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | |
Hyperplasia, mucous cell | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | |
Infiltration, inflammatory cell, subepithelial | examined | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
very slight | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 1 | 0 | 0 | 2 | |
slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |