Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo

Mao, Bin-Hsu; Luo, Yi-Kai; Wang, Bour-Jr; Chen, Chun-Wan; Cheng, Fong-Yu; Lee, Yu-Hsuan; Yan, Shian-Jang; Wang, Ying-Jan

doi:10.1186/s12989-022-00447-0

Table 2 The summary of cytotoxicity and proliferative activity profiles of SCS, LCS, SAS, and LAS

From: Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo

Highly pro-proliferative: viability ≥ 140%; Moderately pro-proliferative: 120% ≤ viability < 140%; Mildly pro-proliferative: 100% ≤ viability < 120%; Highly toxic: viability < 50%; Moderately toxic: 50 ≤ viability < 80%; Mildly toxic: 80% ≤ viability < 100%

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ISSN: 1743-8977

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	SCS	LCS	SAS	LAS
24 h of exposure
BEAS-2B	Highly pro-proliferative at any given doses	Mildly to moderately pro-proliferative at doses greater than or equal to 5 µg/ml	Moderately toxic at doses greater than or equal to 5 µg/ml	Mildly pro-proliferative at doses less than or equal to 10 µg/ml; Mildly toxic at 15 µg/ml
Clone 9	Moderately to highly pro-proliferative at doses greater than or equal to 5 µg/ml	Highly pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly pro-proliferative at doses less than or equal to 10 µg/ml; Mildly toxic at 15 µg/ml
HaCaT	Moderately pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly to moderately pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly pro-proliferative at doses greater than or equal to 10 µg/ml	Moderately pro-proliferative at doses greater than or equal to 5 µg/ml
HEK293	Moderately to highly pro-proliferative at doses less than or equal to 10 µg/ml	Mildly to moderately pro-proliferative at doses greater than or equal to 1 µg/ml	Moderately to highly toxic at doses greater than or equal to 5 µg/ml	Mildly to moderately pro-proliferative at any given doses
THP-1	Mildly pro-proliferative at any given doses	Mildly pro-proliferative at any given doses	Mildly pro-proliferative at any given doses	Mildly pro-proliferative at any given doses
IEC-6	Highly toxic at doses greater than or equal to 5 µg/ml	Highly toxic at doses greater than or equal to 5 µg/ml	Moderately to highly toxic at doses greater than or equal to 1 µg/ml	Highly toxic at doses greater than or equal to 5 µg/ml
AML12	Mildly toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml
48 h of exposure
BEAS-2B	Mildly to moderately pro-proliferative at doses less than or equal to 10 µg/ml; Highly toxic at 15 µg/ml	Moderately proliferative at doses less than or equal to 1 µg/ml; Moderately to high toxic at doses greater than or equal to 5 µg/ml	Moderately to highly toxic at doses greater than or equal to 5 µg/ml	Mildly pro-proliferative at doses less than or equal to 5 µg/ml; Mildly to moderately toxic at doses greater than or equal to 10 µg/ml
Clone 9	Mildly to moderately pro-proliferative at any given doses	Mildly to moderately pro-proliferative at any given doses	Mildly to moderately pro-proliferative at doses greater than or equal to 5 µg/ml	Highly pro-proliferative at doses greater than or equal to 5 µg/ml
HaCaT	Mildly to moderately pro-proliferative at doses less than or equal to 1 µg/ml; Highly pro-proliferative at doses greater than or equal to 5 µg/ml	Moderately to highly pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly to highly pro-proliferative at any given doses	Highly pro-proliferative at doses greater than or equal to 5 µg/ml
HEK293	Highly pro-proliferative at doses less than or equal to 5 µg/ml; Moderately toxic at 15 µg/ml	Mildly pro-proliferative at doses less than or equal to 5 µg/ml; Moderately toxic at 15 µg/ml	Moderately to highly toxic at doses greater than or equal to 5 µg/ml	Mildly to highly pro-proliferative at any given doses
THP-1	Mildly pro-proliferative at any given doses	Mildly to moderately pro-proliferative at any given doses	Moderately to highly pro-proliferative at doses greater than or equal to 5 µg/ml	Mildly to moderately pro-proliferative at any given doses
IEC-6	Moderately to highly toxic at doses greater than or equal to 1 µg/ml	Moderately to highly toxic at doses greater than or equal to 1 µg/ml	Moderately to highly toxic at doses greater than or equal to 1 µg/ml	Moderately to highly toxic at any given doses
AML12	Mildly to moderately toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 30 µg/ml	Mildly to moderately toxic at doses less than or equal to 15 µg/ml; Highly toxic at 30 µg/ml

Particle and Fibre Toxicology

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