| Control | 0.1% SiO2 | 1% SiO2 | 0.1% CeO2 | 1% CeO2 |
---|---|---|---|---|---|
Liver | n = 5 | n = 6 | n = 6 | n = 6 | n = 6 |
 Focal inflammatory infiltrates | 1 (5) | 1 (4), 2(2) | 1 (6) | 1 (6) | 1 (6) |
 Focal necrosis | 1 (2) | 1 (1) | 1 (2) | 0 (6) | 0 (6) |
 Increased interstitial cells | 0 (5) | 2 (1) | 1 (1) | 1 (1) | 1 (1) |
 Increased glycogen | 0 (5) | 0 (6) | 0 (6) | 2 (2), 3 (1) | 0 (6) |
 Vacuolation | 0 (5) | 0 (6) | 0 (6) | 0 (6) | 2 (3) |
Spleen | n = 5 | n = 6 | n = 6 | n = 5* | n = 6 |
 Increased pigment | 2 (1) | 2 (3) | 0 (6) | 2 (2) | 1 (1), 2 (1) |
 Congestion | 0 (5) | 2 (1) | 0 (6) | 0 (5) | 0 (6) |
 Increased extramedullary hematopoiesis | 0 (5) | 0 (6) | 3 (1) | 1 (1) | 2 (1) |
 Increased megakaryocytes | 0 (5) | 0 (6) | 2 (1) | 0 (5) | 0 (6) |
 | *One sample not evaluable due to embedding artefacts | ||||
Small and large intestine | |||||
 | Minimal focal inflammatory infiltrates (intra-mucosal) in all specimens | ||||
 | In some cases, inflammatory infiltrates in adjacent tissue and pancreas with focal vacuolation (grade 2) | ||||
 | Clearly visible goblet cells in PAS stained slides (small intestine + ; large intestine +++) | ||||
 | Partly mucus on surface. Gut associated lymphoid tissue (GALT) in almost all specimens detectable |