| Untreated | Vehicle | DWCNT 0.125 mg/rat | DWCNT 0.250 mg/rat | DWCNT 0.500 mg/rat | MWCNT 0.500 mg/rat |
---|---|---|---|---|---|---|
Granulation tissue count/cm2 mean ± S.D | 1.1 ± 0.35 | 2.4 ± 1.2 | 98.8 ± 31.0*** | 189 ± 32.5***,# | 404.4 ± 88.8***,# | 65.4 ± 11.8** |
Macrophage count/cm2 mean ± S.D | 1.45 ± 0.23 | 6.93 ± 1.47 | 21.72 ± 4.2*** | 33.01 + 6.4***,# | 49.1 + 5.79***,# | 15.88 ± 5.79** |
Alveolar cell PCNA index % | 10.77 ± 3.00 | 18.10 ± 8.65 | 16.51 ± 7.85 | 17.81 ± 7.40 | 25.85 ± 4.74 | 44.52 ± 7.55 ** |
CCL2 pg/mg lung protein mean ± S.D | 3.30 ± 0.28 | 3.65 ± 0.44 | 16.69 ± 4.65*** | 23.36 + 4.33***,# | 22.37 + 3.7***,# | 9.49 ± 0.98*** |
CCL3 pg/mg lung protein mean ± S.D | 6.82 ± 0.56 | 8.19 ± 0.73 | 40.32 ± 10.4** | 69.09 + 7.84***,# | 135.57 + 11***,## | 24.86 ± 8.4* |