Table 2 Male reproductive system AOPs on AOP-Wiki
AOP ID: | Title | KE | AO | Taxonomic Applicability | References |
|---|---|---|---|---|---|
18 | PPARα activation in utero leading to impaired fertility in males | MIE: Activation, PPARα KE1: Decrease, Steroidogenic acute regulatory protein (STAR) KE2: Reduction, Cholesterol transport in mitochondria KE3: Reduction, Testosterone synthesis in Leydig cells KE4: Reduction, Testosterone level KE5: Decrease, Translocator protein (TSPO) | Impaired, Fertility Malformation, Male reproductive tract | Rattus norvegicus Homo sapiens Mus musculus | [138] |
64 | Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility | MIE: Glucocorticoid Receptor Agonist, Activation KE1: Repressed expression of steroidogenic enzymes KE2: Increased apoptosis, decreased number of adult Leydig Cells KE3: Reduction, Testosterone synthesis in Leydig cells KE4: Reduction, testosterone level KE5: Decreased sperm quantity or quality in the adult, Decreased fertility | Impaired, Fertility | Rattus norvegicus | [151] |
207 | NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans | MIE: Activation, NADPH Oxidase KE1: ROS formation KE2: Increase, Oxidative Stress/Activation, PMK-1 P38 MAPK KE3: Activation, HIF-1 KE4: Increased, DNA Damage-Repair KE5: Damaging, Mitochondria KE6: Apoptosis | Reproductive failure | Caenorhabditis elegans | [55] |
208 | Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure | KE1: Activation, JAK/STAT pathway KE2: Activation, TGF-beta pathway | Reproductive failure | Caenorhabditis elegans | [59] |
322 | Alkylation of DNA leading to reduced sperm count | MIE: Alkylation, DNA KE1: Inadequate DNA repair KE2: Increase, DNA strand breaks KE3: Increase, Apoptosis | Reduce, Sperm count | No information | [122] |
323 | PPAR alpha Agonism Impairs Fish Reproduction | MIE: Activation, PPARα KE1: Decreased, cholesterol KE2: Decreased, 11KT KE3: Impaired, Spermatogenesis KE4: impaired, Fertility | No information | Teleost fish | [152] |
444 | Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability | MIE: Deposition of Energy MIE: Increase in reactive oxygen and nitrogen species (RONS) MIE: Increase, DNA damage KE1: Increased, Oxidative Stress KE2: Increase, Apoptosis KE3: Decreased spermatogenesis KE4: Decrease, Fecundity KE5: Decrease, Reproduction | Decrease, Population growth rate | No information | [153] |