Table 1 Parameters used in MPPD modelling of rat lung deposition of α-quartz

Model

Symmetric Sprague Dawley

Body weight (g)

450

FRC volume (mL)

Default for Sprague Dawley rat (4.3578 mL)

URT (Head) volume (mL)

Default for Sprague Dawley rat (0.53668 mL)

Density (g/cm³)

2.6

Diameter (MMAD) (µm)

1.4, 1.6, 1.8, 2

Geometric SD (µm) [32]

2

Concentration (mg/m³)

1

Breathing frequency (min⁻¹)

Default for Sprague Dawley rat, nose only exposure (166 per minute)

Tidal volume (mL)

Default for Sprague Dawley rat, nose only exposure (3.37267 mL)

Inspiratory fraction

Default for Sprague Dawley rat (0.5)

Pause fraction

Default for Sprague Dawley rat (0)

Breathing scenario

Nose only exposure

Clearance rate (day⁻¹)

Deposition only