Dose (mg/kg bw/day) | 0 | 10 | 100 | 1000 |
---|---|---|---|---|
Male | ||||
No. of animals | 5 | 5 | 5 | 5 |
RBC (× 106/μl) | 8.90 ± 0.59 | 8.91 ± 0.28 | 8.90 ± 0.47 | 9.03 ± 0.23 |
HGB (g/dL) | 15.5 ± 0.9 | 15.4 ± 0.5 | 15.5 ± 0.7 | 15.5 ± 0.3 |
HCT (%) | 45.2 ± 3.3 | 45.1 ± 1.8 | 45.3 ± 2.3 | 45.7 ± 0.8 |
MCV (fL) | 50.7 ± 0.7 | 50.5 ± 0.4 | 50.9 ± 0.6 | 50.6 ± 0.4 |
MCH (pg) | 17.5 ± 0.3 | 17.2 ± 0.2 | 17.4 ± 0.2 | 17.2 ± 0.2 |
MCHC (g/dL) | 34.4 ± 0.6 | 34.1 ± 0.5 | 34.2 ± 0.3 | 34.0 ± 0.1 |
RET (%) | 3.16 ± 0.40 | 3.03 ± 0.22 | 2.97 ± 0.21 | 3.01 ± 0.23 |
PLT (× 103/μl) | 512 ± 323 | 751 ± 67 | 730 ± 85 | 774 ± 25 |
WBC (× 103/μl) | 6.75 ± 1.23 | 4.73 ± 0.93* | 5.89 ± 1.35 | 5.10 ± 0.82 |
Differential cell count | ||||
NEUT (%) | 19.7 ± 5.79 | 23.7 ± 4.52 | 28.6 ± 7.99 | 26.5 ± 2.27 |
LYMPH (%) | 75.8 ± 6.15 | 72.9 ± 4.62 | 66.8 ± 7.77 | 69.8 ± 2.78 |
MONO (%) | 2.78 ± 1.11 | 2.56 ± 0.52 | 3.30 ± 2.02 | 2.72 ± 0.54 |
EO (%) | 1.52 ± 1.11 | 0.72 ± 0.16 | 0.98 ± 0.50 | 0.76 ± 0.22 |
BASO (%) | 0.20 ± 0.07 | 0.12 ± 0.11 | 0.24 ± 0.11 | 0.26 ± 0.13 |
Female | ||||
No. of animals | 5 | 5 | 5 | 5 |
RBC (× 106/μl) | 9.06 ± 0.24 | 9.05 ± 0.28 | 9.23 ± 0.34 | 9.17 ± 0.11 |
HGB (g/dL) | 16.1 ± 0.3 | 16.1 ± 0.5 | 16.3 ± 0.6 | 16.1 ± 0.2 |
HCT (%) | 46.8 ± 1.1 | 46.4 ± 1.8 | 47.4 ± 1.9 | 46.8 ± 0.7 |
MCV (fL) | 51.6 ± 0.6 | 51.2 ± 0.5 | 51.3 ± 0.4 | 51.1 ± 0.5 |
MCH (pg) | 17.8 ± 0.1 | 17.8 ± 0.1 | 17.7 ± 0.2 | 17.5 ± 0.1** |
MCHC (g/dL) | 34.4 ± 0.3 | 34.8 ± 0.3 | 34.4 ± 0.2 | 34.3 ± 0.3 |
RET (%) | 2.52 ± 0.18 | 2.62 ± 0.26 | 2.58 ± 0.30 | 2.53 ± 0.45 |
PLT (× 103/μl) | 707 ± 48 | 670 ± 205 | 598 ± 265 | 740 ± 110 |
WBC (× 103/μl) | 4.35 ± 1.41 | 4.04 ± 1.20 | 4.18 ± 1.24 | 4.90 ± 2.20 |
Differential cell count | ||||
NEUT (%) | 17.6 ± 3.09 | 17.7 ± 4.88 | 16.9 ± 5.41 | 18.1 ± 6.58 |
LYMPH (%) | 77.4 ± 3.12 | 74.4 ± 12.15 | 78.1 ± 4.63 | 77.2 ± 7.04 |
MONO (%) | 3.24 ± 0.54 | 3.26 ± 0.89 | 3.24 ± 0.53 | 2.80 ± 0.59 |
EO (%) | 1.52 ± 0.51 | 4.34 ± 6.46 | 1.56 ± 1.15 | 1.64 ± 0.49 |
BASO (%) | 0.18 ± 0.11 | 0.36 ± 0.36 | 0.20 ± 0.12 | 0.30 ± 0.12 |