Dose (mg/kg bw/day) | 0 | 10 | 100 | 1000 |
---|---|---|---|---|
Male | ||||
No. of animals | 5 | 5 | 5 | 5 |
Body weight (g) | 209.5 ± 6.9 | 207.6 ± 9.5 | 207.8 ± 16.3 | 209.2 ± 10.8 |
Absolute (g) | ||||
Brain | 1.801 ± 0.070 | 1.839 ± 0.049 | 1.831 ± 0.026 | 1.816 ± 0.027 |
Thymus | 0.279 ± 0.028 | 0.282 ± 0.021 | 0.291 ± 0.018 | 0.276 ± 0.039 |
Lungs | 0.739 ± 0.058 | 0.772 ± 0.060 | 0.756 ± 0.062 | 0.783 ± 0.049 |
Heart | 0.717 ± 0.066 | 0.719 ± 0.052 | 0.715 ± 0.065 | 0.702 ± 0.053 |
Spleen | 0.480 ± 0.027 | 0.498 ± 0.020 | 0.476 ± 0.037 | 0.481 ± 0.029 |
Liver | 6.007 ± 1.100 | 5.573 ± 0.301 | 5.500 ± 0.576 | 5.518 ± 0.487 |
Adrenals | 0.034 ± 0.003 | 0.035 ± 0.002 | 0.036 ± 0.005 | 0.038 ± 0.004 |
Kidneys | 1.417 ± 0.110 | 1.439 ± 0.096 | 1.377 ± 0.099 | 1.369 ± 0.101 |
Testes | 2.652 ± 0.109 | 2.754 ± 0.036 | 2.700 ± 0.233 | 2.620 ± 0.295 |
Pituitary | 0.008 ± 0.001 | 0.009 ± 0.001 | 0.009 ± 0.002 | 0.008 ± 0.001 |
Thyroid | 0.013 ± 0.002 | 0.016 ± 0.001* | 0.015 ± 0.001 | 0.014 ± 0.001 |
Salivary gland | 0.401 ± 0.032 | 0.400 ± 0.013 | 0.417 ± 0.028 | 0.416 ± 0.035 |
Seminal vesicle | 0.512 ± 0.060 | 0.578 ± 0.075 | 0.569 ± 0.047 | 0.570 ± 0.068 |
Prostate gland | 0.411 ± 0.039 | 0.442 ± 0.053 | 0.468 ± 0.036 | 0.458 ± 0.026 |
Relative (%) | ||||
Brain | 0.860 ± 0.021 | 0.887 ± 0.024 | 0.885 ± 0.068 | 0.870 ± 0.051 |
Thymus | 0.133 ± 0.012 | 0.136 ± 0.009 | 0.141 ± 0.009 | 0.132 ± 0.017 |
Lungs | 0.352 ± 0.023 | 0.372 ± 0.016 | 0.364 ± 0.008 | 0.374 ± 0.013 |
Heart | 0.342 ± 0.022 | 0.346 ± 0.016 | 0.344 ± 0.018 | 0.335 ± 0.010 |
Spleen | 0.229 ± 0.006 | 0.240 ± 0.005 ** | 0.229 ± 0.005 | 0.230 ± 0.002 |
Liver | 2.858 ± 0.429 | 2.685 ± 0.069 | 2.642 ± 0.092 | 2.634 ± 0.098 |
Adrenals | 0.016 ± 0.002 | 0.017 ± 0.001 | 0.017 ± 0.002 | 0.018 ± 0.001 |
Kidneys | 0.676 ± 0.032 | 0.693 ± 0.024 | 0.663 ± 0.016 | 0.654 ± 0.022 |
Testes | 1.267 ± 0.057 | 1.329 ± 0.059 | 1.299 ± 0.044 | 1.257 ± 0.166 |
Pituitary | 0.004 ± 0.000 | 0.004 ± 0.000 | 0.004 ± 0.001 * | 0.004 ± 0.000 |
Thyroid | 0.006 ± 0.001 | 0.008 ± 0.000 * | 0.007 ± 0.000 | 0.007 ± 0.000 |
Salivary gland | 0.191 ± 0.016 | 0.193 ± 0.004 | 0.201 ± 0.007 | 0.199 ± 0.012 |
Seminal vesicle | 0.245 ± 0.033 | 0.279 ± 0.037 | 0.276 ± 0.037 | 0.272 ± 0.025 |
Prostate gland | 0.196 ± 0.018 | 0.212 ± 0.017 | 0.226 ± 0.019 * | 0.219 ± 0.016 |
Female | ||||
No. of animals | 5 | 5 | 5 | 5 |
Body weight (g) | 134.0 ± 6.2 | 131.8 ± 3.2 | 133.4 ± 4.2 | 131.0 ± 4.9 |
Absolute (g) | ||||
Brain | 1.693 ± 0.051 | 1.678 ± 0.064 | 1.680 ± 0.047 | 1.699 ± 0.035 |
Thymus | 0.228 ± 0.015 | 0.233 ± 0.010 | 0.225 ± 0.020 | 0.214 ± 0.013 |
Lungs | 0.625 ± 0.035 | 0.611 ± 0.060 | 0.586 ± 0.028 | 0.566 ± 0.026 |
Heart | 0.504 ± 0.008 | 0.507 ± 0.038 | 0.492 ± 0.026 | 0.497 ± 0.012 |
Spleen | 0.347 ± 0.017 | 0.342 ± 0.009 | 0.356 ± 0.019 | 0.344 ± 0.023 |
Liver | 3.421 ± 0.105 | 3.446 ± 0.124 | 3.326 ± 0.150 | 3.267 ± 0.168 |
Adrenals | 0.041 ± 0.004 | 0.043 ± 0.004 | 0.040 ± 0 .003 | 0.040 ± 0.002 |
Kidneys | 0.928 ± 0.075 | 0.929 ± 0.051 | 0.949 ± 0.033 | 0.956 ± 0.037 |
Ovaries | 0.053 ± 0.004 | 0.055 ± 0.008 | 0.055 ± 0.018 | 0.048 ± 0.012 |
Pituitary | 0.009 ± 0.001 † | 0.011 ± 0.002 | 0.010 ± 0.001 | 0.009 ± 0.002 |
Thyroid | 0.010 ± 0.000 | 0.011 ± 0.001 | 0.010 ± 0.001 | 0.011 ± 0.001 |
Salivary gland | 0.304 ± 0.011 | 0.290 ± 0.022 | 0.305 ± 0.014 | 0.308 ± 0.035 |
Relative (%) | ||||
Brain | 1.266 ± 0.085 | 1.273 ± 0.030 | 1.259 ± 0.020 | 1.298 ± 0.058 |
Thymus | 0.171 ± 0.012 | 0.177 ± 0.005 | 0.168 ± 0.015 | 0.164 ± 0.012 |
Lungs | 0.466 ± 0.016 | 0.463 ± 0.040 | 0.439 ± 0.018 | 0.433 ± 0.021 |
Heart | 0.377 ± 0.016 | 0.384 ± 0.021 | 0.369 ± 0.025 | 0.380 ± 0.015 |
Spleen | 0.259 ± 0.004 | 0.260 ± 0.007 | 0.267 ± 0.009 | 0.263 ± 0.019 |
Liver | 2.556 ± 0.106 | 2.614 ± 0.058 | 2.493 ± 0.111 | 2.494 ± 0.114 |
Adrenals | 0.031 ± 0.004 | 0.033 ± 0.004 | 0.030 ± 0.002 | 0.031 ± 0.001 |
Kidneys | 0.692 ± 0.026 | 0.704 ± 0.024 | 0.711 ± 0.026 | 0.730 ± 0.032 |
Ovaries | 0.040 ± 0.002 | 0.042 ± 0.007 | 0.041 ± 0.012 | 0.037 ± 0.008 |
Pituitary | 0.007 ± 0.000 † | 0.008 ± 0.001 | 0.007 ± 0.001 | 0.007 ± 0.001 |
Thyroid | 0.008 ± 0.000 | 0.008 ± 0.000 | 0.008 ± 0.000 | 0.009 ± 0.000* |
Salivary gland | 0.224 ± 0.013 | 0.220 ± 0.013 | 0.229 ± 0.008 | 0.236 ± 0.032 |