Dose (mg/kg bw/day) | 0 | 100 | 300 | 1000 |
---|---|---|---|---|
Male | ||||
No. of animals | 10 | 10 | 10 | 10 |
Body weight (g) | 291.4 ± 16.4 | 285.8 ± 17.0 | 297.3 ± 16.8 | 284.4 ± 16.7 |
Absolute | ||||
Brain (g) | 1.911 ± 0.046 | 1.914 ± 0.034 | 1.916 ± 0.030 | 1.902 ± 0.035 |
Thymus (g) | 0.168 ± 0.016 | 0.162 ± 0.028 | 0.182 ± 0.018 | 0.159 ± 0.026 |
Lungs (g) | 0.906 ± 0.042 | 0.875 ± 0.061 | 0.923 ± 0.057 | 0.893 ± 0.061 |
Heart (g) | 0.829 ± 0.058 | 0.829 ± 0.042 | 0.851 ± 0.039 | 0.833 ± 0.054 |
Spleen (g) | 0.570 ± 0.043 | 0.569 ± 0.049 | 0.583 ± 0.035 | 0.553 ± 0.035 |
Liver (g) | 6.553 ± 0.644 | 6.400 ± 0.468 | 6.649 ± 0.399 | 6.183 ± 0.501 |
Adrenals (g) | 0.035 ± 0.004 | 0.034 ± 0.003 | 0.034 ± 0.003 | 0.035 ± 0.003 |
Kidneys (g) | 1.578 ± 0.076 | 1.622 ± 0.104 | 1.613 ± 0.086 | 1.586 ± 0.098 |
Testes (g) | 2.944 ± 0.116 | 2.964 ± 0.293 | 2.912 ± 0.268 | 2.949 ± 0.346 |
Pituitary (mg) | 6.61 ± 0.83 | 6.68 ± 0.80 | 7.12 ± 0.77 | 6.91 ± 0.75 |
Thyroid (mg) | 14.63 ± 1.61 | 12.59 ± 2.44 | 13.87 ± 2.69 | 12.33 ± 1.84 |
Salivary gland (g) | 0.453 ± 0.033 | 0.448 ± 0.026 | 0.465 ± 0.018 | 0.446 ± 0.030 |
Seminal vesicle (g) | 0.844 ± 0.122 | 0.804 ± 0.097 | 0.897 ± 0.093 | 0.830 ± 0.087 |
Prostate gland (g) | 0.638 ± 0.082 | 0.667 ± 0.064 | 0.696 ± 0.072 | 0.680 ± 0.071 |
Relative (%) | ||||
Brain | 0.659 ± 0.035 | 0.672 ± 0.039 | 0.646 ± 0.031 | 0.671 ± 0.035 |
Thymus | 0.059 ± 0.005 | 0.056 ± 0.008 | 0.061 ± 0.008 | 0.056 ± 0.010 |
Lungs | 0.312 ± 0.017 | 0.340 ± 0.109 | 0.311 ± 0.014 | 0.314 ± 0.018 |
Heart | 0.284 ± 0.009 | 0.290 ± 0.008 | 0.286 ± 0.011 | 0.293 ± 0.015 |
Spleen | 0.196 ± 0.014 | 0.199 ± 0.008 | 0.196 ± 0.008 | 0.194 ± 0.007 |
Liver | 2.245 ± 0.107 | 2.238 ± 0.046 | 2.236 ± 0.029 | 2.172 ± 0.073 |
Adrenals | 0.012 ± 0.001 | 0.012 ± 0.001 | 0.011 ± 0.001 | 0.012 ± 0.001 |
Kidneys | 0.538 ± 0.026 | 0.568 ± 0.022 ** | 0.543 ± 0.011 | 0.558 ± 0.019 |
Testes | 1.012 ± 0.054 | 1.039 ± 0.099 | 0.981 ± 0.084 | 1.036 ± 0.085 |
Pituitary | 0.002 ± 0.000 | 0.002 ± 0.000 | 0.002 ± 0.000 | 0.002 ± 0.000 |
thyroid | 0.005 ± 0.001 | 0.004 ± 0.001 | 0.005 ± 0.001 | 0.004 ± 0.001 |
Salivary gland | 0.155 ± 0.007 | 0.157 ± 0.005 | 0.157 ± 0.008 | 0.157 ± 0.009 |
Seminal vesicle | 0.290 ± 0.042 | 0.281 ± 0.029 | 0.303 ± 0.038 | 0.292 ± 0.030 |
Prostate gland | 0.219 ± 0.024 | 0.234 ± 0.020 | 0.235 ± 0.027 | 0.240 ± 0.027 |
Female | ||||
No. of animals | 10 | 10 | 10 | 10 |
Body weight (g) | 173.0 ± 5.3 | 171.1 ± 5.3 | 170.3 ± 7.1 | 169.4 ± 7.1 |
Absolute | ||||
Brain (g) | 1.796 ± 0.028 | 1.787 ± 0.031 | 1.779 ± 0.030 | 1.784 ± 0.037 |
Thymus (g) | 0.158 ± 0.015 | 0.152 ± 0.018 | 0.147 ± 0.008 | 0.154 ± 0.015 |
Lungs (g) | 0.676 ± 0.029 | 0.694 ± 0.036 | 0.674 ± 0.134 | 0.686 ± 0.039 |
Heart (g) | 0.555 ± 0.018 | 0.548 ± 0.032 | 0.554 ± 0.030 | 0.540 ± 0.027 |
Spleen (g) | 0.386 ± 0.019 | 0.385 ± 0.013 | 0.372 ± 0.023 | 0.374 ± 0.027 |
Liver (g) | 3.751 ± 0.122 | 3.693 ± 0.149 | 3.640 ± 0.182 | 3.624 ± 0.176 |
Adrenals (g) | 0.040 ± 0.003 | 0.041 ± 0.004 | 0.039 ± 0.006 | 0.040 ± 0.006 |
Kidneys (g) | 1.021 ± 0.057 | 1.027 ± 0.032 | 1.000 ± 0.051 | 1.001 ± 0.041 |
Ovaries (g) | 0.049 ± 0.006 | 0.045 ± 0.009 | 0.044 ± 0.006 | 0.043 ± 0.007 |
Pituitary (mg) | 11.49 ± 2.02 | 11.72 ± 1.33 | 10.58 ± 1.97 | 11.44 ± 1.92 |
Thyroid (mg) | 10.95 ± 2.36 | 9.54 ± 0.94 | 11.35 ± 1.35 | 11.07 ± 1.12 |
Salivary gland (g) | 0.326 ± 0.012 | 0.335 ± 0.011 | 0.333 ± 0.018 | 0.333 ± 0.023 |
Relative (%) | ||||
Brain | 1.039 ± 0.029 | 1.045 ± 0.028 | 1.047 ± 0.048 | 1.055 ± 0.061 |
Thymus | 0.091 ± 0.007 | 0.089 ± 0.009 | 0.087 ± 0.005 | 0.091 ± 0.008 |
Lungs | 0.391 ± 0.014 | 0.406 ± 0.023 | 0.396 ± 0.076 | 0.405 ± 0.026 |
Heart | 0.321 ± 0.016 | 0.321 ± 0.016 | 0.325 ± 0.013 | 0.319 ± 0.013 |
Spleen | 0.223 ± 0.009 | 0.225 ± 0.009 | 0.218 ± 0.011 | 0.221 ± 0.020 |
Liver | 2.169 ± 0.063 | 2.160 ± 0.095 | 2.138 ± 0.061 | 2.140 ± 0.092 |
Adrenals | 0.023 ± 0.001 | 0.024 ± 0.003 | 0.023 ± 0.003 | 0.023 ± 0.004 |
Kidneys | 0.590 ± 0.029 | 0.601 ± 0.020 | 0.587 ± 0.020 | 0.592 ± 0.029 |
Ovaries | 0.028 ± 0.003 | 0.026 ± 0.005 | 0.026 ± 0.003 | 0.025 ± 0.004 |
Pituitary | 0.007 ± 0.001 | 0.007 ± 0.001 | 0.006 ± 0.001 | 0.007 ± 0.001 |
Thyroid | 0.006 ± 0.001 | 0.006 ± 0.001 | 0.007 ± 0.001 | 0.007 ± 0.001 |
Salivary gland | 0.189 ± 0.006 | 0.196 ± 0.009 | 0.195 ± 0.008 | 0.197 ± 0.010 |