Male | Female | ||||||||
---|---|---|---|---|---|---|---|---|---|
Dose (mg/kg bw/day) | 0 | 100 | 300 | 1000 | 0 | 100 | 300 | 1000 | |
No. of animals | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |
Eye | Atrophy, outer retina (minimal) | 4 | – | – | 0 | 4 | – | – | 0 |
Heart | Infiltrate, inflammatory cell (minimal, mild) | 6 | – | – | 4 | 1 | – | – | 0 |
(6, 0) | (3, 1) | (1, 0) | |||||||
Pituitary gland | Aberrant craniopharyngeal structure (mild) | 0 | – | – | 1 | 0 | – | – | 0 |
Cyst, pars nervosa (minimal) | 0 | – | – | 0 | 0 | – | – | 1 | |
Nasal cavity | Yellowish brown material, mucosa, level 1 (minimal) | 0 | 1 | 2 | 7** | 0 | 0 | 2 | 7** |
Yellowish brown material, mucosa, level 2 (minimal) | 0 | 1 | 6* | 9** | 0 | 0 | 5* | 7** | |
Yellowish brown material, mucosa, level 3 (minimal, mild) | 0 | 3 | 9** | 8** | 0 | 2 | 6* | 7** | |
(3, 0) | (9, 0) | (6, 2) | (2, 0) | (6, 0) | (7, 0) | ||||
Yellowish brown material, nasopharynx-associated lymphoid tissue, level 3 (minimal) | 0 | 6* | 7** | 8** | 0 | 5* | 5* | 9** | |
Hypertrophy, mucous cell, respiratory epithelium, level 1 (minimal, mild) | 2 | 1 | 1 | 6 | 0 | 2 | 0 | 7** | |
(2, 0) | (1, 0) | (1, 0) | (6, 0) | (2, 0) | (4, 3) | ||||
Hypertrophy, mucous cell, respiratory epithelium, level 2 (minimal) | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 5* | |
Hypertrophy, mucous cell, nasopharyngeal duct, level 3 (minimal) | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 7** | |
Lung | Yellowish brown material, alveolar (Present) | 0 | 1 | 3 | 8** | 0 | 2 | 1 | 6* |
Yellowish brown material, bronchus-associated lymphoid tissue (minimal, mild) | 0 | 2 | 2 | 5* | 0 | 2 | 3 | 4 | |
(2, 0) | (1, 1) | (5, 0) | (2, 0) | (3, 0) | (3, 1) | ||||
Trachea | Yellowish brown material, subepithelial (minimal) | 0 | 2 | 2 | 7** | 0 | 2 | 1 | 4 |
Lymph node, cervical | Yellowish brown material (minimal) | 0 | 0 | 6* | 10** | 0 | 4 | 6* | 8** |
Lymph node, mediastinal | Yellowish brown material (minimal, mild) | 0 | 3 | 4 | 7** | 0† | 2† | 4 | 5* |
(3, 0) | (4, 0) | (7, 0) | (2, 0) | (3, 1) | (4, 1) | ||||
Esophagus | Yellowish brown material, lumen (present) | 0 | – | – | 9** | 0 | – | – | 2 |
Stomach | Yellowish brown material, lumen (present) | 0 | – | – | 10** | 0 | – | – | 10** |
Duodenum | Yellowish brown material, lumen (present) | 0 | – | – | 10** | 0 | – | – | 9** |
Jejunum | Yellowish brown material, lumen (present) | 0 | – | – | 9** | 0 | – | – | 7** |
Ileum | Yellowish brown material, lumen (present) | 0 | 6* | 6* | 10** | 0 | 7** | 8** | 10** |
Yellowish brown material, Payer's patch (minimal) | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 3 | |
Cecum | Yellowish brown material, lumen (present) | 0 | – | – | 10** | 0 | – | – | 10** |
Colon | Yellowish brown material, lumen (present) | 0 | – | – | 10** | 0 | – | – | 9** |
Rectum | Yellowish brown material, lumen (present) | 0 | – | – | 10** | 0 | – | – | 4 |
Liver | Hepatodiaphragmatic nodule (Present) | 3 | – | – | 1 | 0 | – | – | 0 |
Infiltrate, mononuclear cell (minimal) | 0 | – | – | 0 | 2 | – | – | 1 | |
Testis | Dilatation, tubule (mild) | 0 | – | – | 1 | – | – | – | – |
Degeneration/Atrophy, tubule (mild) | 0 | – | – | 1 | |||||
Epididymis | Sperm, decreased, lumen (mild) | 0 | – | – | 1 | – | – | – | – |
Prostate | Infiltrate, inflammatory cell (minimal) | 2 | – | – | 3 | – | – | – | – |