Fig. 2
Effect of PM2.5, the DRP-1 inhibitor Mdivi-1, the OPA1 activator BGP-15 and of DRP1 knockdown (KD) and OPA1 overexpression (OE) on inflammatory gene expression in A549 cells. Fold changes in IL-1β (A), IL-6 (B), IL-18 (C) and CXCL-8 (D) mRNA expression in A549 cells exposed to PM2.5 in the presence and absence of Mdivi-1 and BGP-15. Fold changes in IL-1β (E), IL-6 (F), IL-18 (G) and CXCL-8 (H) mRNA expression in A549 cells exposed to PM2.5 in the presence and absence of DRP1-KD and OPA1-OE. Mean values and data from individual experiments are shown. One-way ANOVA with Bonferroni’s post hoc test (for equal variance) or Dunnett’s T3 post hoc test (for unequal variance) was performed for comparisons among multiple groups. *P < 0.05, **P < 0.01, ***P < 0.001