Fig. 1
Acute PM2.5 exposure induces retinal edema by damaging RPE in mice. A Schematic diagram of PM2.5-exposed C57BL/6J mouse model establishment. OCT, optical coherence tomography; OCTA, optical coherence tomography angiography. B Schematic diagram of the structural composition of oBRB. C OCT images of the retina in mice after exposure of PBS or PM2.5 for 3 days. Retinal edema is indicated with red arrows. PBS, phosphate buffer saline. D Incidence of retinal edema in mice exposed to PBS or PM2.5 for 3 days. E Hydration rate of retina in mice treated with PBS or PM2.5 for 3 days (n = 14). F Immunofluorescence analysis of RPE specific marker RPE65 on mouse RPE flat-mounts. Bridging-like loss of RPE cells (yellow arrows) and enlargement of cell gaps (white arrows) are indicated. Data in (E) are presented as mean ± SD. *p < 0.05