Skip to main content

Advertisement

Table 1 Relative distribution of AuNP (singlets, small or large agglomerates) in lung tissue compartments [%]

From: Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Animals* Lining layer Macs Epithelium
   Epithelial surface Type Icells Type II cells Type I & Type II Total epithelium
Tg 0 h 1.0 ± 1.4 24.0 ± 5.9 69.2 ± 4.9 6.7 ± 1.2 0.1 ± 0.2 6.8 ± 1.0 76.0 ± 5.9
Tg 24 h 1.0 ± 1.4 63.0 ± 18.9 15.5 ± 4.8 19.9 ± 12.0 1.5 ± 2.1 21.4 ± 14.2 37.0 ± 19.0
Tg All 1.0 ± 1.2 43.5 ± 25.3 42.4 ± 31.3 13.3 ± 10.4 0.8 ± 1.5 14.1 ± 11.8 56.5 ± 25.3
Wt 0 h 3.5 ± 4.9 58.3 ± 41.4 35.3 ± 32.2 2.5 ± 3.5 0.5 ± 0.7 3.0 ± 4.2 38.3 ± 36.4
Wt 24 h 4.5 ± 6.4 82.8 ± 0.2 9.5 ± 5.0 2.1 ± 1.5 0.1 ± 0.1 2.2 ± 1.6 11.7 ± 6.6
Wt All 4.0 ± 4.7 70.5 ± 27.8 22.4 ± 24.0 2.3 ± 2.2 0.3 ± 0.5 2.6 ± 2.7 25.0 ± 26.3
  1. Tg, Scnn1b-transgenic mice; Wt, wild-type mice. Macs, macrophages, Type I and Type II cells, alveolar epithelial cells. Total epithelium, all AuNP associated with the alveolar epithelium, i.e. attached to and within alveolar (type I and type II) epithelial cells.
  2. Data are presented as the mean ± SD.
  3. *, n = 2 per genotype and time point.