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  1. Methodology

    An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials

    Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known...

    Glen M. DeLoid, Yanli Wang, Klara Kapronezai, Laura Rubio Lorente, Roujie Zhang, Georgios Pyrgiotakis, Nagarjun V. Konduru, Maria Ericsson, Jason C. White, Roberto De La Torre-Roche, Hang Xiao, David Julian McClements and Philip Demokritou

    Particle and Fibre Toxicology 2017 14:40

    Published on: 13 October 2017

  2. Research

    In vitro toxicoproteomic analysis of A549 human lung epithelial cells exposed to urban air particulate matter and its water-soluble and insoluble fractions

    Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition is complex and variable due to source contribution and atmospheric transformation. In this study, we used an in vitro ...

    Ngoc Q. Vuong, Dalibor Breznan, Patrick Goegan, Julie S. O’Brien, Andrew Williams, Subramanian Karthikeyan, Premkumari Kumarathasan and Renaud Vincent

    Particle and Fibre Toxicology 2017 14:39

    Published on: 2 October 2017

  3. Research

    Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice

    We and other groups have demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused oxidative stress and inflammation, which have been shown to be strongly associated with genotoxic and carcinogenic e...

    Rong Wan, Yiqun Mo, Zhenyu Zhang, Mizu Jiang, Shichuan Tang and Qunwei Zhang

    Particle and Fibre Toxicology 2017 14:38

    Published on: 18 September 2017

  4. Research

    Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

    The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining an...

    Jake Nikota, Allyson Banville, Laura Rose Goodwin, Dongmei Wu, Andrew Williams, Carole Lynn Yauk, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

    Particle and Fibre Toxicology 2017 14:37

    Published on: 13 September 2017

  5. Research

    Imipramine blocks acute silicosis in a mouse model

    Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Im...

    Rupa Biswas, Kevin L. Trout, Forrest Jessop, Jack R. Harkema and Andrij Holian

    Particle and Fibre Toxicology 2017 14:36

    Published on: 11 September 2017

  6. Research

    Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

    Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation...

    Maja Hullmann, Catrin Albrecht, Damiën van Berlo, Miriam E. Gerlofs-Nijland, Tina Wahle, Agnes W. Boots, Jean Krutmann, Flemming R. Cassee, Thomas A. Bayer and Roel P. F. Schins

    Particle and Fibre Toxicology 2017 14:35

    Published on: 30 August 2017

  7. Research

    NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration

    PM2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for the global burden of disease. Whereas increasing evidence has linked the adverse roles of PM2.5 with cardiovascular and res...

    Tingting Ku, Ben Li, Rui Gao, Yingying Zhang, Wei Yan, Xiaotong Ji, Guangke Li and Nan Sang

    Particle and Fibre Toxicology 2017 14:34

    Published on: 29 August 2017

  8. Research

    Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation

    Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesit...

    Laura Pergoli, Laura Cantone, Chiara Favero, Laura Angelici, Simona Iodice, Eva Pinatel, Mirjam Hoxha, Laura Dioni, Marilena Letizia, Benedetta Albetti, Letizia Tarantini, Federica Rota, Pier Alberto Bertazzi, Amedea Silvia Tirelli, Vincenza Dolo, Andrea Cattaneo…

    Particle and Fibre Toxicology 2017 14:32

    Published on: 24 August 2017

  9. Research

    Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration

    Copper oxide nanomaterials (CuO NMs) are exploited in a diverse array of products including antimicrobials, inks, cosmetics, textiles and food contact materials. There is therefore a need to assess the toxicit...

    Victor C. Ude, David M. Brown, Luca Viale, Nilesh Kanase, Vicki Stone and Helinor J. Johnston

    Particle and Fibre Toxicology 2017 14:31

    Published on: 23 August 2017

  10. Research

    Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function

    Epidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergi...

    Maria Ferrini, Sophia Carvalho, Yoon Hee Cho, Britten Postma, Lucas Miranda Marques, Kent Pinkerton, Kevan Roberts and Zeina Jaffar

    Particle and Fibre Toxicology 2017 14:30

    Published on: 22 August 2017

  11. Research

    Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

    Nano- and microscale copper oxide particles (CuO NP, CuO MP) are applied for manifold purposes, enhancing exposure and thus the potential risk of adverse health effects. Based on the pronounced in vitro cytoto...

    Bettina Maria Strauch, Rebecca Katharina Niemand, Nicola Lisa Winkelbeiner and Andrea Hartwig

    Particle and Fibre Toxicology 2017 14:28

    Published on: 1 August 2017

  12. Research

    Multi-walled carbon nanotubes-induced alterations in microRNA let-7 and its targets activate a protection mechanism by conferring a developmental timing control

    Multi-walled carbon nanotubes (MWCNTs) have been produced and applied for diverse purposes. MWCNTs can potentially cause the adverse effects on organisms. MicroRNA let-7 and its targets of HBL-1 and LIN-41 play a...

    Li Zhao, Hanxiao Wan, Qizhan Liu and Dayong Wang

    Particle and Fibre Toxicology 2017 14:27

    Published on: 20 July 2017

  13. Research

    STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

    Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that contrasting rigidities of tangled (t) versus rod-l...

    Katherine S. Duke, Alexia J. Taylor-Just, Mark D. Ihrie, Kelly A. Shipkowski, Elizabeth A. Thompson, Erinn C. Dandley, Gregory N. Parsons and James C. Bonner

    Particle and Fibre Toxicology 2017 14:26

    Published on: 17 July 2017

  14. Research

    Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

    As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was ...

    James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard…

    Particle and Fibre Toxicology 2017 14:25

    Published on: 17 July 2017

  15. Research

    Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

    Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Generally less information is given on heal...

    Daniela Schwotzer, Heinrich Ernst, Dirk Schaudien, Heiko Kock, Gerhard Pohlmann, Clemens Dasenbrock and Otto Creutzenberg

    Particle and Fibre Toxicology 2017 14:23

    Published on: 12 July 2017

  16. Research

    A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop

    Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of developing respiratory, cardiovascular, and neurological disorders. Based on animal inhalation stud...

    Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen, Kiao Inthavong and Jiyuan Tu

    Particle and Fibre Toxicology 2017 14:24

    Published on: 12 July 2017

  17. Review

    Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

    Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential physical scaffolding for the cellular constituent...

    Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, Mikhail I. Shtilman, Kirill Golokhvast and Aristidis M. Tsatsakis

    Particle and Fibre Toxicology 2017 14:22

    Published on: 24 June 2017

  18. Research

    MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

    Dendritic cells (DCs) are specialized first-line sensors of foreign materials invading the organism. These sentinel cells rely on pattern recognition receptors such as Nod-like or Toll-like receptors (TLRs) to...

    Hans Christian Winkler, Julian Kornprobst, Peter Wick, Lea Maria von Moos, Ioannis Trantakis, Elisabeth Maria Schraner, Barbara Bathke, Hubertus Hochrein, Mark Suter and Hanspeter Naegeli

    Particle and Fibre Toxicology 2017 14:21

    Published on: 23 June 2017

  19. Research

    Programming of mouse obesity by maternal exposure to concentrated ambient fine particles

    Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown that exposure to ambient fine particles (PM2.5) is ...

    Minjie Chen, Xiaoke Wang, Ziying Hu, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Xiaobo Qin, Yuhao Zhang and Zhekang Ying

    Particle and Fibre Toxicology 2017 14:20

    Published on: 23 June 2017

  20. Research

    Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

    The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular imp...

    Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid and Tobias Stoeger

    Particle and Fibre Toxicology 2017 14:19

    Published on: 20 June 2017

  21. Research

    Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

    The use of multiwalled carbon nanotubes (MWCNT) is increasing due to a growing use in a variety of products across several industries. Thus, occupational exposure is also of increasing concern, particularly si...

    H. K. L. Johansson, J. S. Hansen, B. Elfving, S. P. Lund, Z. O. Kyjovska, S. Loft, K. K. Barfod, P. Jackson, U. Vogel and K. S. Hougaard

    Particle and Fibre Toxicology 2017 14:17

    Published on: 30 May 2017

  22. Research

    Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

    Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preex...

    Alex P. Carll, Samir M. Crespo, Mauricio S. Filho, Douglas H. Zati, Brent A. Coull, Edgar A. Diaz, Rodrigo D. Raimundo, Thomas N. G. Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E. Lawrence, David M. Garner, Brigham S. Perry, Jack R. Harkema and John J. Godleski

    Particle and Fibre Toxicology 2017 14:16

    Published on: 25 May 2017

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