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  1. Precisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver cation (Ag+), nor is it known how AgNP damage is transmitt...

    Authors: Monica M. Rohde, Christina M. Snyder, John Sloop, Shane R. Solst, George L. Donati, Douglas R. Spitz, Cristina M. Furdui and Ravi Singh

    Citation: Particle and Fibre Toxicology 2021 18:37

    Content type: Research

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  2. Considering the inevitability for humans to be frequently exposed to nanoparticles (NPs), understanding the biosafety of NPs is important for rational usage. As an important part of the innate immune system, m...

    Authors: Xiaoting Jin, Haiyi Yu, Ze Zhang, Tenglong Cui, Qi Wu, Xiaolei Liu, Jie Gao, Xingchen Zhao, Jianbo Shi, Guangbo Qu and Guibin Jiang

    Citation: Particle and Fibre Toxicology 2021 18:36

    Content type: Research

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  3. Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability.

    Authors: Ponnusamy Manogaran Gopinath, Krishna Sundar Twayana, Palaniyandi Ravanan, John Thomas, Amitava Mukherjee, David F. Jenkins and Natarajan Chandrasekaran

    Citation: Particle and Fibre Toxicology 2021 18:35

    Content type: Research

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  4. Multiwalled carbon nanotubes (MWCNT) are an increasingly utilized engineered nanomaterial that pose the potential for significant risk of exposure-related health outcomes. The mechanism(s) underlying MWCNT-ind...

    Authors: Tamara L. Young, Ekaterina Mostovenko, Jesse L. Denson, Jessica G. Begay, Selita N. Lucas, Guy Herbert, Katherine Zychowski, Russell Hunter, Raul Salazar, Ting Wang, Kelly Fraser, Aaron Erdely, Andrew K. Ottens and Matthew J. Campen

    Citation: Particle and Fibre Toxicology 2021 18:34

    Content type: Research

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  5. Metal oxide nanoparticles (NPs) are increasingly used in many industrial and biomedical applications, hence their impact on occupational and public health has become a concern. In recent years, interest on the...

    Authors: Antonella Camaioni, Micol Massimiani, Valentina Lacconi, Andrea Magrini, Antonietta Salustri, Georgios A. Sotiriou, Dilpreet Singh, Dimitrios Bitounis, Beatrice Bocca, Anna Pino, Flavia Barone, Valentina Prota, Ivo Iavicoli, Manuel Scimeca, Elena Bonanno, Flemming R. Cassee…

    Citation: Particle and Fibre Toxicology 2021 18:33

    Content type: Research

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  7. Exposure to indoor air pollution from solid fuel combustion is associated with lung diseases and cancer. This study investigated the cytotoxicity and molecular mechanisms of biomass combustion-derived particle...

    Authors: Shaorui Ke, Qi Liu, Xinlian Zhang, Yuhan Yao, Xudong Yang and Guodong Sui

    Citation: Particle and Fibre Toxicology 2021 18:31

    Content type: Research

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  8. Nanoparticles have been studied for brain imaging, diagnosis, and drug delivery owing to their versatile properties due to their small sizes. However, there are growing concerns that nanoparticles may exert to...

    Authors: Tae Hwan Shin, Da Yeon Lee, Balachandran Manavalan, Shaherin Basith, Yun-Cheol Na, Cheolho Yoon, Hyeon-Seong Lee, Man Jeong Paik and Gwang Lee

    Citation: Particle and Fibre Toxicology 2021 18:30

    Content type: Research

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  9. An important aspect of nanomaterial (NM) risk assessment is establishing relationships between physicochemical properties and key events governing the toxicological pathway leading to adverse outcomes. The dif...

    Authors: Frédéric Cosnier, Carole Seidel, Sarah Valentino, Otmar Schmid, Sébastien Bau, Ulla Vogel, Jérôme Devoy and Laurent Gaté

    Citation: Particle and Fibre Toxicology 2021 18:29

    Content type: Research

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  10. Expanding biomedical application of anatase titanium dioxide (TiO2) nanoparticles (NPs) is raising the public concern on its potential health hazards. Here, we demonstrated that TiO2 NPs can increase phosphatidyl...

    Authors: Yiying Bian, Han-Young Chung, Ok-Nam Bae, Kyung-Min Lim, Jin-Ho Chung and Jingbo Pi

    Citation: Particle and Fibre Toxicology 2021 18:28

    Content type: Research

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  11. This study aims to investigate the effects of water soluble particulate matter (WSPM) on the viability and protein expression profile of human lung adenocarcinoma cell A549 in the Bayou Obo rare earth mining a...

    Authors: Yuan Xia, Xulong Zhang, Dejun Sun, Yumin Gao, Xiaoe Zhang, Li Wang, Qingjun Cai, Qihao Wang and Juan Sun

    Citation: Particle and Fibre Toxicology 2021 18:27

    Content type: Research

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  12. The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the mucosa and to protect the body from damage of harmful substanc...

    Authors: Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand and Marie Carriere

    Citation: Particle and Fibre Toxicology 2021 18:26

    Content type: Review

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  13. Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety. Costs and ethical concerns of animal testing drive a nee...

    Authors: Emilio Di Ianni, Johanna Samulin Erdem, Peter Møller, Nicklas Mønster Sahlgren, Sarah Søs Poulsen, Kristina Bram Knudsen, Shan Zienolddiny, Anne Thoustrup Saber, Håkan Wallin, Ulla Vogel and Nicklas Raun Jacobsen

    Citation: Particle and Fibre Toxicology 2021 18:25

    Content type: Research

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  14. Exposure to air pollution exerts direct effects on respiratory organs; however, molecular alterations underlying air pollution-induced pulmonary injury remain unclear. In this study, we investigated the effect...

    Authors: Yu-Teng Jheng, Denise Utami Putri, Hsiao-Chi Chuang, Kang-Yun Lee, Hsiu-Chu Chou, San-Yuan Wang and Chia-Li Han

    Citation: Particle and Fibre Toxicology 2021 18:24

    Content type: Research

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  15. As the application of silica nanomaterials continues to expand, increasing chances of its exposure to the human body and potential harm are anticipated. Although the toxicity of silica nanomaterials is assumed...

    Authors: Masahide Inoue, Koji Sakamoto, Atsushi Suzuki, Shinya Nakai, Akira Ando, Yukihiko Shiraki, Yoshio Nakahara, Mika Omura, Atsushi Enomoto, Ikuhiko Nakase, Makoto Sawada and Naozumi Hashimoto

    Citation: Particle and Fibre Toxicology 2021 18:21

    Content type: Research

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  16. Widespread use of silver in its different forms raises concerns about potential adverse effects after ingestion, the main exposure route for humans. The aim of this study was to investigate in CD-1 (ICR) male ...

    Authors: Camilla Recordati, Marcella De Maglie, Claudia Cella, Simona Argentiere, Saverio Paltrinieri, Silvia Bianchessi, Marco Losa, Fabio Fiordaliso, Alessandro Corbelli, Gianpaolo Milite, Federica Aureli, Marilena D’Amato, Andrea Raggi, Francesco Cubadda, Sabina Soldati, Cristina Lenardi…

    Citation: Particle and Fibre Toxicology 2021 18:23

    Content type: Research

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  17. Air pollution derived from combustion is associated with considerable cardiorespiratory morbidity and mortality in addition to environmental effects. Replacing petrodiesel with biodiesel may have ecological be...

    Authors: Jon Unosson, Mikael Kabéle, Christoffer Boman, Robin Nyström, Ioannis Sadiktsis, Roger Westerholm, Ian S. Mudway, Esme Purdie, Jennifer Raftis, Mark R. Miller, Nicholas L. Mills, David E. Newby, Anders Blomberg, Thomas Sandström and Jenny A. Bosson

    Citation: Particle and Fibre Toxicology 2021 18:22

    Content type: Research

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  18. Micro- and nanoplastic pollution has become a global environmental problem. Nanoplastics in the environment are still hard to detect because of analysis technology limitations. It is believed that when micropl...

    Authors: Boxuan Liang, Yizhou Zhong, Yuji Huang, Xi Lin, Jun Liu, Li Lin, Manjiang Hu, Junying Jiang, Mingzhu Dai, Bo Wang, Bingli Zhang, Hao Meng, Jesse Justin J. Lelaka, Haixia Sui, Xingfen Yang and Zhenlie Huang

    Citation: Particle and Fibre Toxicology 2021 18:20

    Content type: Research

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  19. Although airborne fine particulate matter (PM) pollution has been demonstrated as an independent risk factor for pulmonary and cardiovascular diseases, their currently-available toxicological data is still far...

    Authors: Xiaoting Jin, Hongyan Yu, Baoqiang Wang, Zhendong Sun, Ze Zhang, Qian S. Liu, Yuxin Zheng, Qunfang Zhou and Guibin Jiang

    Citation: Particle and Fibre Toxicology 2021 18:19

    Content type: Research

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  20. Respirable stone- and mineral particles may be a major constituent in occupational and ambient air pollution and represent a possible health hazard. However, with exception of quartz and asbestos, little is kn...

    Authors: Vegard Sæter Grytting, Magne Refsnes, Johan Øvrevik, Marit Sigrid Halle, Jasmin Schönenberger, Roelant van der Lelij, Brynhild Snilsberg, Tonje Skuland, Richard Blom and Marit Låg

    Citation: Particle and Fibre Toxicology 2021 18:18

    Content type: Research

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  21. Disruption of microbiota balance may result in severe diseases in animals and phytotoxicity in plants. While substantial concerns have been raised on engineered nanomaterial (ENM) induced hazard effects (e.g., lu...

    Authors: Huizhen Zheng, Zonglin Gu, Yanxia Pan, Jie Chen, Qianqian Xie, Shujuan Xu, Meng Gao, Xiaoming Cai, Shengtang Liu, Weili Wang, Wei Li, Xi Liu, Zaixing Yang, Ruhong Zhou and Ruibin Li

    Citation: Particle and Fibre Toxicology 2021 18:17

    Content type: Research

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  22. A very pure multi-walled carbon nanotube (MWCNT) that was shown to have very low toxicity in vitro, was evaluated for lung and systemic effects and distribution following inhalation exposure.

    Authors: Christopher T. Migliaccio, Raymond F. Hamilton Jr, Pamela K. Shaw, Joseph F. Rhoderick, Sanghamitra Deb, Rohit Bhargava, Jack R. Harkema and Andrij Holian

    Citation: Particle and Fibre Toxicology 2021 18:16

    Content type: Research

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  23. Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air po...

    Authors: Victor Yuji Yariwake, Janaína Iannicelli Torres, Amandda Rakell Peixoto dos Santos, Sarah Cristina Ferreira Freitas, Kátia De Angelis, Sylvia Costa Lima Farhat, Niels Olsen Saraiva Câmara and Mariana Matera Veras

    Citation: Particle and Fibre Toxicology 2021 18:15

    Content type: Research

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  24. Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in ambient air and contaminates many occupational settings. Airway remodeling assessed using computerized tomography (CT) correlates ...

    Authors: Hong Liu, Jianyu Li, Qianli Ma, Jinglong Tang, Menghui Jiang, Xue Cao, Li Lin, Nan Kong, Shanfa Yu, Akshay Sood, Yuxin Zheng, Shuguang Leng and Wei Han

    Citation: Particle and Fibre Toxicology 2021 18:14

    Content type: Research

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  25. The increasing use of metal nanoparticles in industry and biomedicine raises the risk for unintentional exposure. The ability of metal nanoparticles to penetrate the skin ranges from stopping at the stratum co...

    Authors: Jiali Yuan, Yue Zhang, Yuanbao Zhang, Yiqun Mo and Qunwei Zhang

    Citation: Particle and Fibre Toxicology 2021 18:13

    Content type: Research

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  26. Exercise-induced bronchoconstriction (EIB) is a transient airway narrowing, occurring during or shortly after intensive exercise. It is highly prevalent in non-asthmatic outdoor endurance athletes suggesting a...

    Authors: Tatjana Decaesteker, Eliane Vanhoffelen, Kristel Trekels, Anne-Charlotte Jonckheere, Jonathan Cremer, Arno Vanstapel, Ellen Dilissen, Dominique Bullens, Lieven J. Dupont and Jeroen A. Vanoirbeek

    Citation: Particle and Fibre Toxicology 2021 18:12

    Content type: Research

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  27. Air pollution exposure and idiopathic pulmonary fibrosis (IPF) cause a poor prognosis after SARS-CoV-2 infection, but the underlying mechanisms are not well explored. Angiotensin-converting enzyme 2 (ACE2) and...

    Authors: Hsin-Hsien Li, Chen-Chi Liu, Tien-Wei Hsu, Jiun-Han Lin, Jyuan-Wei Hsu, Anna Fen-Yau Li, Yi-Chen Yeh, Shih-Chieh Hung and Han-Shui Hsu

    Citation: Particle and Fibre Toxicology 2021 18:11

    Content type: Research

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  28. Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the ocular surface, with limited research on the impact of PM2.5 on intraocular...

    Authors: Liping Li, Chao Xing, Ji Zhou, Liangliang Niu, Bin Luo, Maomao Song, Jingping Niu, Ye Ruan, Xinghuai Sun and Yuan Lei

    Citation: Particle and Fibre Toxicology 2021 18:10

    Content type: Research

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  29. In vitro models are widely used in nanotoxicology. In these assays, a careful documentation of the fraction of nanomaterials that reaches the cells, i.e. the in vitro delivered dose, is a critical element for ...

    Authors: Dominique Lison, Saloua Ibouraadaten, Sybille van den Brule, Milica Todea, Adriana Vulpoi, Flaviu Turcu, Christina Ziemann, Otto Creutzenberg, James C. Bonner, Marcel Ameloot and Hannelore Bové

    Citation: Particle and Fibre Toxicology 2021 18:9

    Content type: Methodology

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  30. Up to 44% of particulates of food-grade titanium dioxide (TiO2) are in nanoscale, while the effect and combined effect of which with other substances on intestinal barrier haven’t been fully understood yet. This ...

    Authors: Yongliang Zhang, Shumin Duan, Ying Liu and Yun Wang

    Citation: Particle and Fibre Toxicology 2021 18:8

    Content type: Research

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  31. Ambient air pollution by particulate matters, including diesel exhaust particles (DEP), is a major cause of cardiovascular and metabolic mortality worldwide. The mechanisms by which DEP cause these adverse out...

    Authors: Sybille van den Brule, Margaux Rappe, Jérôme Ambroise, Caroline Bouzin, Chantal Dessy, Adrien Paquot, Giulio G. Muccioli and Dominique Lison

    Citation: Particle and Fibre Toxicology 2021 18:7

    Content type: Research

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  32. Cerium (Ce) is a rare earth element, rapidly oxidizing to form CeO2, and currently used in numerous commercial applications, especially as nanoparticles (NP). The potential health effects of Ce remain uncertain, ...

    Authors: Balasubramanyam Annangi, Zhuyi Lu, Jonathan Bruniaux, Audrey Ridoux, Vanessa Marques da Silva, Delphine Vantelon, Jorge Boczkowski and Sophie Lanone

    Citation: Particle and Fibre Toxicology 2021 18:6

    Content type: Research

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  33. Inhalation exposure to nanomaterials in workplaces can include a mixture of multiple nanoparticles. Such ambient nanoparticles can be of high dissolution or low dissolution in vivo and we wished to determine w...

    Authors: Jin Kwon Kim, Hoi Pin Kim, Jung Duck Park, Kangho Ahn, Woo Young Kim, Mary Gulumian, Günter Oberdörster and Il Je Yu

    Citation: Particle and Fibre Toxicology 2021 18:5

    Content type: Research

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  34. Depending on their distinct properties, titanium dioxide nanoparticles (TiO2-NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release and public concerns. ...

    Authors: Yen-Ju Chan, Po-Lin Liao, Chi-Hao Tsai, Yu-Wen Cheng, Fan-Li Lin, Jau-Der Ho, Ching-Yi Chen and Ching-Hao Li

    Citation: Particle and Fibre Toxicology 2021 18:4

    Content type: Research

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  35. Exposure to traffic-generated emissions is associated with the development and exacerbation of inflammatory lung disorders such as chronic obstructive pulmonary disorder (COPD) and idiopathic pulmonary fibrosi...

    Authors: Sarah Daniel, Danielle Phillippi, Leah J. Schneider, Kayla N. Nguyen, Julie Mirpuri and Amie K. Lund

    Citation: Particle and Fibre Toxicology 2021 18:3

    Content type: Research

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  36. In recent years, wildland fires have occurred more frequently and with increased intensity in many fire-prone areas. In addition to the direct life and economic losses attributable to wildfires, the emitted sm...

    Authors: Hao Chen, James M. Samet, Philip A. Bromberg and Haiyan Tong

    Citation: Particle and Fibre Toxicology 2021 18:2

    Content type: Review

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  37. Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. This ...

    Authors: Monia Savi, Leonardo Bocchi, Francesca Cacciani, Rocchina Vilella, Annamaria Buschini, Alessio Perotti, Serena Galati, Serena Montalbano, Silvana Pinelli, Caterina Frati, Emilia Corradini, Federico Quaini, Roberta Ruotolo, Donatella Stilli and Massimiliano Zaniboni

    Citation: Particle and Fibre Toxicology 2021 18:1

    Content type: Research

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  38. Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxici...

    Authors: Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend…

    Citation: Particle and Fibre Toxicology 2020 17:62

    Content type: Research

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  39. Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate m...

    Authors: Shuang Liang, Jingyi Zhang, Ruihong Ning, Zhou Du, Jiangyan Liu, Joe Werelagi Batibawa, Junchao Duan and Zhiwei Sun

    Citation: Particle and Fibre Toxicology 2020 17:61

    Content type: Review

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  40. Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization...

    Authors: Alexia J. Taylor-Just, Mark D. Ihrie, Katherine S. Duke, Ho Young Lee, Dorothy J. You, Salik Hussain, Vamsi K. Kodali, Christina Ziemann, Otto Creutzenberg, Adriana Vulpoi, Flaviu Turcu, Monica Potara, Milica Todea, Sybille van den Brule, Dominique Lison and James C. Bonner

    Citation: Particle and Fibre Toxicology 2020 17:60

    Content type: Research

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  41. Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects o...

    Authors: Hsiao-Chi Chuang, Hsin-Chang Chen, Pei-Jui Chai, Ho-Tang Liao, Chang-Fu Wu, Chia-Ling Chen, Ming-Kai Jhan, Hui-I Hsieh, Kuen-Yuh Wu, Ta-Fu Chen and Tsun-Jen Cheng

    Citation: Particle and Fibre Toxicology 2020 17:59

    Content type: Research

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  42. Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.

    Authors: Lauren H. Wyatt, Robert B. Devlin, Ana G. Rappold, Martin W. Case and David Diaz-Sanchez

    Citation: Particle and Fibre Toxicology 2020 17:58

    Content type: Research

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  44. Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowl...

    Authors: Eva Bongaerts, Tim S. Nawrot, Thessa Van Pee, Marcel Ameloot and Hannelore Bové

    Citation: Particle and Fibre Toxicology 2020 17:56

    Content type: Review

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  45. Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk...

    Authors: Sara B. Fournier, Jeanine N. D’Errico, Derek S. Adler, Stamatina Kollontzi, Michael J. Goedken, Laura Fabris, Edward J. Yurkow and Phoebe A. Stapleton

    Citation: Particle and Fibre Toxicology 2020 17:55

    Content type: Research

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  46. Information on particle deposition, retention, and clearance is important when evaluating the risk of inhaled nanomaterials to human health. The revised Organization Economic Cooperation and Development (OECD)...

    Authors: Hoi Pin Kim, Jin Kwon Kim, Mi Seong Jo, Jung Duck Park, Kangho Ahn, Mary Gulumian, Günter Oberdörster and Il Je Yu

    Citation: Particle and Fibre Toxicology 2020 17:54

    Content type: Research

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  47. Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the ph...

    Authors: Xiaoli Feng, Yaqing Zhang, Chao Zhang, Xuan Lai, Yanli Zhang, Junrong Wu, Chen Hu and Longquan Shao

    Citation: Particle and Fibre Toxicology 2020 17:53

    Content type: Review

    Published on:

  48. While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier. In...

    Authors: Timothy Smyth, Janelle Veazey, Sophia Eliseeva, David Chalupa, Alison Elder and Steve N. Georas

    Citation: Particle and Fibre Toxicology 2020 17:52

    Content type: Research

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  49. Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80–90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos,...

    Authors: Dina Mourad Saleh, William T. Alexander, Takamasa Numano, Omnia Hosny Mohamed Ahmed, Sivagami Gunasekaran, David B. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Hiroshi Takase, Jiegou Xu, Aya Naiki-Ito, Satoru Takahashi, Akihiko Hirose, Makoto Ohnishi, Jun Kanno and Hiroyuki Tsuda

    Citation: Particle and Fibre Toxicology 2020 17:48

    Content type: Research

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  50. Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part o...

    Authors: A. Guillard, E. Gaultier, C. Cartier, L. Devoille, J. Noireaux, L. Chevalier, M. Morin, F. Grandin, M. Z. Lacroix, C. Coméra, A. Cazanave, A. de Place, V. Gayrard, V. Bach, K. Chardon, N. Bekhti…

    Citation: Particle and Fibre Toxicology 2020 17:51

    Content type: Research

    Published on:

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Particle and Fibre Toxicology

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