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  1. Research

    Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration

    Copper oxide nanomaterials (CuO NMs) are exploited in a diverse array of products including antimicrobials, inks, cosmetics, textiles and food contact materials. There is therefore a need to assess the toxicit...

    Victor C. Ude, David M. Brown, Luca Viale, Nilesh Kanase, Vicki Stone and Helinor J. Johnston

    Particle and Fibre Toxicology 2017 14:31

    Published on: 23 August 2017

  2. Research

    Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function

    Epidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergi...

    Maria Ferrini, Sophia Carvalho, Yoon Hee Cho, Britten Postma, Lucas Miranda Marques, Kent Pinkerton, Kevan Roberts and Zeina Jaffar

    Particle and Fibre Toxicology 2017 14:30

    Published on: 22 August 2017

  4. Research

    Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

    Nano- and microscale copper oxide particles (CuO NP, CuO MP) are applied for manifold purposes, enhancing exposure and thus the potential risk of adverse health effects. Based on the pronounced in vitro cytoto...

    Bettina Maria Strauch, Rebecca Katharina Niemand, Nicola Lisa Winkelbeiner and Andrea Hartwig

    Particle and Fibre Toxicology 2017 14:28

    Published on: 1 August 2017

  5. Research

    Multi-walled carbon nanotubes-induced alterations in microRNA let-7 and its targets activate a protection mechanism by conferring a developmental timing control

    Multi-walled carbon nanotubes (MWCNTs) have been produced and applied for diverse purposes. MWCNTs can potentially cause the adverse effects on organisms. MicroRNA let-7 and its targets of HBL-1 and LIN-41 play a...

    Li Zhao, Hanxiao Wan, Qizhan Liu and Dayong Wang

    Particle and Fibre Toxicology 2017 14:27

    Published on: 20 July 2017

  6. Research

    STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

    Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that contrasting rigidities of tangled (t) versus rod-l...

    Katherine S. Duke, Alexia J. Taylor-Just, Mark D. Ihrie, Kelly A. Shipkowski, Elizabeth A. Thompson, Erinn C. Dandley, Gregory N. Parsons and James C. Bonner

    Particle and Fibre Toxicology 2017 14:26

    Published on: 17 July 2017

  7. Research

    Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

    As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was ...

    James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard…

    Particle and Fibre Toxicology 2017 14:25

    Published on: 17 July 2017

  8. Research

    Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

    Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Generally less information is given on heal...

    Daniela Schwotzer, Heinrich Ernst, Dirk Schaudien, Heiko Kock, Gerhard Pohlmann, Clemens Dasenbrock and Otto Creutzenberg

    Particle and Fibre Toxicology 2017 14:23

    Published on: 12 July 2017

  9. Research

    A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop

    Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of developing respiratory, cardiovascular, and neurological disorders. Based on animal inhalation stud...

    Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen, Kiao Inthavong and Jiyuan Tu

    Particle and Fibre Toxicology 2017 14:24

    Published on: 12 July 2017

  10. Review

    Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

    Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential physical scaffolding for the cellular constituent...

    Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, Mikhail I. Shtilman, Kirill Golokhvast and Aristidis M. Tsatsakis

    Particle and Fibre Toxicology 2017 14:22

    Published on: 24 June 2017

  11. Research

    MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

    Dendritic cells (DCs) are specialized first-line sensors of foreign materials invading the organism. These sentinel cells rely on pattern recognition receptors such as Nod-like or Toll-like receptors (TLRs) to...

    Hans Christian Winkler, Julian Kornprobst, Peter Wick, Lea Maria von Moos, Ioannis Trantakis, Elisabeth Maria Schraner, Barbara Bathke, Hubertus Hochrein, Mark Suter and Hanspeter Naegeli

    Particle and Fibre Toxicology 2017 14:21

    Published on: 23 June 2017

  12. Research

    Programming of mouse obesity by maternal exposure to concentrated ambient fine particles

    Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown that exposure to ambient fine particles (PM2.5) is ...

    Minjie Chen, Xiaoke Wang, Ziying Hu, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Xiaobo Qin, Yuhao Zhang and Zhekang Ying

    Particle and Fibre Toxicology 2017 14:20

    Published on: 23 June 2017

  13. Research

    Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

    The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular imp...

    Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid and Tobias Stoeger

    Particle and Fibre Toxicology 2017 14:19

    Published on: 20 June 2017

  15. Research

    Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

    The use of multiwalled carbon nanotubes (MWCNT) is increasing due to a growing use in a variety of products across several industries. Thus, occupational exposure is also of increasing concern, particularly si...

    H. K. L. Johansson, J. S. Hansen, B. Elfving, S. P. Lund, Z. O. Kyjovska, S. Loft, K. K. Barfod, P. Jackson, U. Vogel and K. S. Hougaard

    Particle and Fibre Toxicology 2017 14:17

    Published on: 30 May 2017

  16. Research

    Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

    Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preex...

    Alex P. Carll, Samir M. Crespo, Mauricio S. Filho, Douglas H. Zati, Brent A. Coull, Edgar A. Diaz, Rodrigo D. Raimundo, Thomas N. G. Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E. Lawrence, David M. Garner, Brigham S. Perry, Jack R. Harkema and John J. Godleski

    Particle and Fibre Toxicology 2017 14:16

    Published on: 25 May 2017

  17. Research

    Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment

    Graphite carbon nanofibers (GCNF) have emerged as a potential alternative of carbon nanotubes (CNT) for various biomedical applications due to their superior physico-chemical properties. Therefore in-depth und...

    Sandeep Mittal, Pradeep Kumar Sharma, Ratnakar Tiwari, Raja Gopal Rayavarapu, Jai Shankar, Lalit Kumar Singh Chauhan and Alok Kumar Pandey

    Particle and Fibre Toxicology 2017 14:15

    Published on: 28 April 2017

  19. Research Article

    Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation

    The wide application of engineered nanoparticles has induced increasing exposure to humans and environment, which led to substantial concerns on their biosafety. Some metal oxides (MOx) have shown severe toxic...

    Xiaoming Cai, Anson Lee, Zhaoxia Ji, Cynthia Huang, Chong Hyun Chang, Xiang Wang, Yu-Pei Liao, Tian Xia and Ruibin Li

    Particle and Fibre Toxicology 2017 14:13

    Published on: 21 April 2017

  20. Research

    In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation

    Previous work has demonstrated size, surface charge and skin barrier dependent penetration of nanoparticles into the viable layers of mouse skin. The goal of this work was to characterize the tissue distributi...

    Samreen Jatana, Brian C. Palmer, Sarah J. Phelan, Robert Gelein and Lisa A. DeLouise

    Particle and Fibre Toxicology 2017 14:12

    Published on: 14 April 2017

  22. Research

    Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults

    Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations ha...

    Jenny Rissler, Anders Gudmundsson, Hanna Nicklasson, Erik Swietlicki, Per Wollmer and Jakob Löndahl

    Particle and Fibre Toxicology 2017 14:10

    Published on: 8 April 2017

  24. Research

    Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons

    Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and...

    Karina Lindner, Michael Ströbele, Sandra Schlick, Sina Webering, André Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Hüttmann, Holger Heine…

    Particle and Fibre Toxicology 2017 14:8

    Published on: 21 March 2017

  25. Research

    Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter

    During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental partic...

    Sebastian G. Klein, Sébastien Cambier, Jennifer Hennen, Sylvain Legay, Tommaso Serchi, Inge Nelissen, Aline Chary, Elisa Moschini, Andreas Krein, Brunhilde Blömeke and Arno C. Gutleb

    Particle and Fibre Toxicology 2017 14:7

    Published on: 6 March 2017

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