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  1. Although airborne fine particulate matter (PM) pollution has been demonstrated as an independent risk factor for pulmonary and cardiovascular diseases, their currently-available toxicological data is still far...

    Authors: Xiaoting Jin, Hongyan Yu, Baoqiang Wang, Zhendong Sun, Ze Zhang, Qian S. Liu, Yuxin Zheng, Qunfang Zhou and Guibin Jiang

    Citation: Particle and Fibre Toxicology 2021 18:19

    Content type: Research

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  2. Respirable stone- and mineral particles may be a major constituent in occupational and ambient air pollution and represent a possible health hazard. However, with exception of quartz and asbestos, little is kn...

    Authors: Vegard Sæter Grytting, Magne Refsnes, Johan Øvrevik, Marit Sigrid Halle, Jasmin Schönenberger, Roelant van der Lelij, Brynhild Snilsberg, Tonje Skuland, Richard Blom and Marit Låg

    Citation: Particle and Fibre Toxicology 2021 18:18

    Content type: Research

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  3. Disruption of microbiota balance may result in severe diseases in animals and phytotoxicity in plants. While substantial concerns have been raised on engineered nanomaterial (ENM) induced hazard effects (e.g., lu...

    Authors: Huizhen Zheng, Zonglin Gu, Yanxia Pan, Jie Chen, Qianqian Xie, Shujuan Xu, Meng Gao, Xiaoming Cai, Shengtang Liu, Weili Wang, Wei Li, Xi Liu, Zaixing Yang, Ruhong Zhou and Ruibin Li

    Citation: Particle and Fibre Toxicology 2021 18:17

    Content type: Research

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  4. A very pure multi-walled carbon nanotube (MWCNT) that was shown to have very low toxicity in vitro, was evaluated for lung and systemic effects and distribution following inhalation exposure.

    Authors: Christopher T. Migliaccio, Raymond F. Hamilton Jr, Pamela K. Shaw, Joseph F. Rhoderick, Sanghamitra Deb, Rohit Bhargava, Jack R. Harkema and Andrij Holian

    Citation: Particle and Fibre Toxicology 2021 18:16

    Content type: Research

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  5. Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air po...

    Authors: Victor Yuji Yariwake, Janaína Iannicelli Torres, Amandda Rakell Peixoto dos Santos, Sarah Cristina Ferreira Freitas, Kátia De Angelis, Sylvia Costa Lima Farhat, Niels Olsen Saraiva Câmara and Mariana Matera Veras

    Citation: Particle and Fibre Toxicology 2021 18:15

    Content type: Research

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  6. Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in ambient air and contaminates many occupational settings. Airway remodeling assessed using computerized tomography (CT) correlates ...

    Authors: Hong Liu, Jianyu Li, Qianli Ma, Jinglong Tang, Menghui Jiang, Xue Cao, Li Lin, Nan Kong, Shanfa Yu, Akshay Sood, Yuxin Zheng, Shuguang Leng and Wei Han

    Citation: Particle and Fibre Toxicology 2021 18:14

    Content type: Research

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  7. The increasing use of metal nanoparticles in industry and biomedicine raises the risk for unintentional exposure. The ability of metal nanoparticles to penetrate the skin ranges from stopping at the stratum co...

    Authors: Jiali Yuan, Yue Zhang, Yuanbao Zhang, Yiqun Mo and Qunwei Zhang

    Citation: Particle and Fibre Toxicology 2021 18:13

    Content type: Research

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  8. Exercise-induced bronchoconstriction (EIB) is a transient airway narrowing, occurring during or shortly after intensive exercise. It is highly prevalent in non-asthmatic outdoor endurance athletes suggesting a...

    Authors: Tatjana Decaesteker, Eliane Vanhoffelen, Kristel Trekels, Anne-Charlotte Jonckheere, Jonathan Cremer, Arno Vanstapel, Ellen Dilissen, Dominique Bullens, Lieven J. Dupont and Jeroen A. Vanoirbeek

    Citation: Particle and Fibre Toxicology 2021 18:12

    Content type: Research

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  9. Air pollution exposure and idiopathic pulmonary fibrosis (IPF) cause a poor prognosis after SARS-CoV-2 infection, but the underlying mechanisms are not well explored. Angiotensin-converting enzyme 2 (ACE2) and...

    Authors: Hsin-Hsien Li, Chen-Chi Liu, Tien-Wei Hsu, Jiun-Han Lin, Jyuan-Wei Hsu, Anna Fen-Yau Li, Yi-Chen Yeh, Shih-Chieh Hung and Han-Shui Hsu

    Citation: Particle and Fibre Toxicology 2021 18:11

    Content type: Research

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  10. Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the ocular surface, with limited research on the impact of PM2.5 on intraocular...

    Authors: Liping Li, Chao Xing, Ji Zhou, Liangliang Niu, Bin Luo, Maomao Song, Jingping Niu, Ye Ruan, Xinghuai Sun and Yuan Lei

    Citation: Particle and Fibre Toxicology 2021 18:10

    Content type: Research

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  11. In vitro models are widely used in nanotoxicology. In these assays, a careful documentation of the fraction of nanomaterials that reaches the cells, i.e. the in vitro delivered dose, is a critical element for ...

    Authors: Dominique Lison, Saloua Ibouraadaten, Sybille van den Brule, Milica Todea, Adriana Vulpoi, Flaviu Turcu, Christina Ziemann, Otto Creutzenberg, James C. Bonner, Marcel Ameloot and Hannelore Bové

    Citation: Particle and Fibre Toxicology 2021 18:9

    Content type: Methodology

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  12. Up to 44% of particulates of food-grade titanium dioxide (TiO2) are in nanoscale, while the effect and combined effect of which with other substances on intestinal barrier haven’t been fully understood yet. This ...

    Authors: Yongliang Zhang, Shumin Duan, Ying Liu and Yun Wang

    Citation: Particle and Fibre Toxicology 2021 18:8

    Content type: Research

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  13. Ambient air pollution by particulate matters, including diesel exhaust particles (DEP), is a major cause of cardiovascular and metabolic mortality worldwide. The mechanisms by which DEP cause these adverse out...

    Authors: Sybille van den Brule, Margaux Rappe, Jérôme Ambroise, Caroline Bouzin, Chantal Dessy, Adrien Paquot, Giulio G. Muccioli and Dominique Lison

    Citation: Particle and Fibre Toxicology 2021 18:7

    Content type: Research

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  14. Cerium (Ce) is a rare earth element, rapidly oxidizing to form CeO2, and currently used in numerous commercial applications, especially as nanoparticles (NP). The potential health effects of Ce remain uncertain, ...

    Authors: Balasubramanyam Annangi, Zhuyi Lu, Jonathan Bruniaux, Audrey Ridoux, Vanessa Marques da Silva, Delphine Vantelon, Jorge Boczkowski and Sophie Lanone

    Citation: Particle and Fibre Toxicology 2021 18:6

    Content type: Research

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  15. Inhalation exposure to nanomaterials in workplaces can include a mixture of multiple nanoparticles. Such ambient nanoparticles can be of high dissolution or low dissolution in vivo and we wished to determine w...

    Authors: Jin Kwon Kim, Hoi Pin Kim, Jung Duck Park, Kangho Ahn, Woo Young Kim, Mary Gulumian, Günter Oberdörster and Il Je Yu

    Citation: Particle and Fibre Toxicology 2021 18:5

    Content type: Research

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  16. Depending on their distinct properties, titanium dioxide nanoparticles (TiO2-NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release and public concerns. ...

    Authors: Yen-Ju Chan, Po-Lin Liao, Chi-Hao Tsai, Yu-Wen Cheng, Fan-Li Lin, Jau-Der Ho, Ching-Yi Chen and Ching-Hao Li

    Citation: Particle and Fibre Toxicology 2021 18:4

    Content type: Research

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  17. Exposure to traffic-generated emissions is associated with the development and exacerbation of inflammatory lung disorders such as chronic obstructive pulmonary disorder (COPD) and idiopathic pulmonary fibrosi...

    Authors: Sarah Daniel, Danielle Phillippi, Leah J. Schneider, Kayla N. Nguyen, Julie Mirpuri and Amie K. Lund

    Citation: Particle and Fibre Toxicology 2021 18:3

    Content type: Research

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  18. In recent years, wildland fires have occurred more frequently and with increased intensity in many fire-prone areas. In addition to the direct life and economic losses attributable to wildfires, the emitted sm...

    Authors: Hao Chen, James M. Samet, Philip A. Bromberg and Haiyan Tong

    Citation: Particle and Fibre Toxicology 2021 18:2

    Content type: Review

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  19. Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. This ...

    Authors: Monia Savi, Leonardo Bocchi, Francesca Cacciani, Rocchina Vilella, Annamaria Buschini, Alessio Perotti, Serena Galati, Serena Montalbano, Silvana Pinelli, Caterina Frati, Emilia Corradini, Federico Quaini, Roberta Ruotolo, Donatella Stilli and Massimiliano Zaniboni

    Citation: Particle and Fibre Toxicology 2021 18:1

    Content type: Research

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  20. Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxici...

    Authors: Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend…

    Citation: Particle and Fibre Toxicology 2020 17:62

    Content type: Research

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  21. Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate m...

    Authors: Shuang Liang, Jingyi Zhang, Ruihong Ning, Zhou Du, Jiangyan Liu, Joe Werelagi Batibawa, Junchao Duan and Zhiwei Sun

    Citation: Particle and Fibre Toxicology 2020 17:61

    Content type: Review

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  22. Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization...

    Authors: Alexia J. Taylor-Just, Mark D. Ihrie, Katherine S. Duke, Ho Young Lee, Dorothy J. You, Salik Hussain, Vamsi K. Kodali, Christina Ziemann, Otto Creutzenberg, Adriana Vulpoi, Flaviu Turcu, Monica Potara, Milica Todea, Sybille van den Brule, Dominique Lison and James C. Bonner

    Citation: Particle and Fibre Toxicology 2020 17:60

    Content type: Research

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  23. Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects o...

    Authors: Hsiao-Chi Chuang, Hsin-Chang Chen, Pei-Jui Chai, Ho-Tang Liao, Chang-Fu Wu, Chia-Ling Chen, Ming-Kai Jhan, Hui-I Hsieh, Kuen-Yuh Wu, Ta-Fu Chen and Tsun-Jen Cheng

    Citation: Particle and Fibre Toxicology 2020 17:59

    Content type: Research

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  24. Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.

    Authors: Lauren H. Wyatt, Robert B. Devlin, Ana G. Rappold, Martin W. Case and David Diaz-Sanchez

    Citation: Particle and Fibre Toxicology 2020 17:58

    Content type: Research

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  26. Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowl...

    Authors: Eva Bongaerts, Tim S. Nawrot, Thessa Van Pee, Marcel Ameloot and Hannelore Bové

    Citation: Particle and Fibre Toxicology 2020 17:56

    Content type: Review

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  27. Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk...

    Authors: Sara B. Fournier, Jeanine N. D’Errico, Derek S. Adler, Stamatina Kollontzi, Michael J. Goedken, Laura Fabris, Edward J. Yurkow and Phoebe A. Stapleton

    Citation: Particle and Fibre Toxicology 2020 17:55

    Content type: Research

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  28. Information on particle deposition, retention, and clearance is important when evaluating the risk of inhaled nanomaterials to human health. The revised Organization Economic Cooperation and Development (OECD)...

    Authors: Hoi Pin Kim, Jin Kwon Kim, Mi Seong Jo, Jung Duck Park, Kangho Ahn, Mary Gulumian, Günter Oberdörster and Il Je Yu

    Citation: Particle and Fibre Toxicology 2020 17:54

    Content type: Research

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  29. Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the ph...

    Authors: Xiaoli Feng, Yaqing Zhang, Chao Zhang, Xuan Lai, Yanli Zhang, Junrong Wu, Chen Hu and Longquan Shao

    Citation: Particle and Fibre Toxicology 2020 17:53

    Content type: Review

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  30. While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier. In...

    Authors: Timothy Smyth, Janelle Veazey, Sophia Eliseeva, David Chalupa, Alison Elder and Steve N. Georas

    Citation: Particle and Fibre Toxicology 2020 17:52

    Content type: Research

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  31. Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80–90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos,...

    Authors: Dina Mourad Saleh, William T. Alexander, Takamasa Numano, Omnia Hosny Mohamed Ahmed, Sivagami Gunasekaran, David B. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Hiroshi Takase, Jiegou Xu, Aya Naiki-Ito, Satoru Takahashi, Akihiko Hirose, Makoto Ohnishi, Jun Kanno and Hiroyuki Tsuda

    Citation: Particle and Fibre Toxicology 2020 17:48

    Content type: Research

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  32. Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part o...

    Authors: A. Guillard, E. Gaultier, C. Cartier, L. Devoille, J. Noireaux, L. Chevalier, M. Morin, F. Grandin, M. Z. Lacroix, C. Coméra, A. Cazanave, A. de Place, V. Gayrard, V. Bach, K. Chardon, N. Bekhti…

    Citation: Particle and Fibre Toxicology 2020 17:51

    Content type: Research

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  33. The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confir...

    Authors: Ru Ma, Yi Qi, Xinying Zhao, Xueyan Li, Xuejing Sun, Piye Niu, Yanbo Li, Caixia Guo, Rui Chen and Zhiwei Sun

    Citation: Particle and Fibre Toxicology 2020 17:50

    Content type: Research

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  34. Exposure to particulate matter (PM) from wood combustion represents a global health risk, encompassing diverse exposure sources; indoor exposures due to cooking in developing countries, ambient PM exposures fr...

    Authors: Carley Schwartz, Anette Kocbach Bølling and Christopher Carlsten

    Citation: Particle and Fibre Toxicology 2020 17:49

    Content type: Review

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  35. Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the...

    Authors: Jinglong Tang, Wenting Cheng, Jinling Gao, Yanting Li, Ruyong Yao, Nathaniel Rothman, Qing Lan, Matthew J. Campen, Yuxin Zheng and Shuguang Leng

    Citation: Particle and Fibre Toxicology 2020 17:47

    Content type: Research

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  36. With the development of zinc oxide nanoparticles (ZnO NPs) in the field of nanotechnology, their toxicological effects are attracting increasing attention, and the mechanisms for ZnO NPs neurotoxicity remain o...

    Authors: Zixuan Liu, Xuying Lv, Lei Xu, Xuting Liu, Xiangyu Zhu, Erqun Song and Yang Song

    Citation: Particle and Fibre Toxicology 2020 17:46

    Content type: Research

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  37. Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the par...

    Authors: Falko Frenzel, Laura König-Mattern, Valerie Stock, Linn Voss, Maxi B. Paul, Holger Sieg, Albert Braeuning, Andreas Voigt and Linda Böhmert

    Citation: Particle and Fibre Toxicology 2020 17:45

    Content type: Short report

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  38. Accurate knowledge of cell−/tissue-delivered dose plays a pivotal role in inhalation toxicology studies, since it is the key parameter for hazard assessment and translation of in vitro to in vivo dose-response...

    Authors: Yaobo Ding, Patrick Weindl, Anke-Gabriele Lenz, Paula Mayer, Tobias Krebs and Otmar Schmid

    Citation: Particle and Fibre Toxicology 2020 17:44

    Content type: Methodology

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  39. The quantification of nanomaterials accumulated in various organs is crucial in studying their toxicity and toxicokinetics. However, some types of nanomaterials, including carbon nanomaterials (CNMs), are diff...

    Authors: Dong-Keun Lee, Soyeon Jeon, Jiyoung Jeong, Kyung Seuk Song and Wan-Seob Cho

    Citation: Particle and Fibre Toxicology 2020 17:43

    Content type: Research

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  40. The toxicity of released metallic particles generated in metal-on-metal (MoM) total hip arthroplasty (THA) using cobalt chromium (CoCr) has raised concerns regarding their safety amongst both surgeons and the ...

    Authors: Jing Xu, Junyao Yang, Jian Chen, Xiaoli Zhang, Yuanhao Wu, Alister Hart, Agata Nyga and Julia C. Shelton

    Citation: Particle and Fibre Toxicology 2020 17:42

    Content type: Research

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  41. Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress i...

    Authors: Yu-Chen Chen, Tzu-Yi Chuang, Chen-Wei Liu, Chi-Wei Liu, Tzu-Lin Lee, Tsai-Chun Lai and Yuh-Lien Chen

    Citation: Particle and Fibre Toxicology 2020 17:41

    Content type: Research

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  42. Engineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-...

    Authors: Jayme P. Coyle, Raymond C. Derk, Tiffany G. Kornberg, Dilpreet Singh, Jake Jensen, Sherri Friend, Robert Mercer, Todd A. Stueckle, Philip Demokritou, Yon Rojanasakul and Liying W. Rojanasakul

    Citation: Particle and Fibre Toxicology 2020 17:40

    Content type: Research

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  43. Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and i...

    Authors: Rongrong Wu, Johan Högberg, Mikael Adner, Patricia Ramos-Ramírez, Ulla Stenius and Huiyuan Zheng

    Citation: Particle and Fibre Toxicology 2020 17:39

    Content type: Research

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  44. Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to at...

    Authors: Katja Maria Bendtsen, Louise Gren, Vilhelm Berg Malmborg, Pravesh Chandra Shukla, Martin Tunér, Yona J. Essig, Annette M. Krais, Per Axel Clausen, Trine Berthing, Katrin Loeschner, Nicklas Raun Jacobsen, Henrik Wolff, Joakim Pagels and Ulla Birgitte Vogel

    Citation: Particle and Fibre Toxicology 2020 17:38

    Content type: Research

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  45. Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly con...

    Authors: Yu-Wen Chen, Mei-Zi Huang, Chyi-Liang Chen, Chieh-Ying Kuo, Chia-Yu Yang, Chuan Chiang-Ni, Yi-Ywan M. Chen, Chia-Ming Hsieh, Hui-Yu Wu, Ming-Ling Kuo, Cheng-Hsun Chiu and Chih-Ho Lai

    Citation: Particle and Fibre Toxicology 2020 17:37

    Content type: Research

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  46. Exposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system...

    Authors: Siri A. N. Holme, Torben Sigsgaard, Jørn A. Holme and Gitte Juel Holst

    Citation: Particle and Fibre Toxicology 2020 17:36

    Content type: Review

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  47. Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have b...

    Authors: Irini M. Dijkhoff, Barbara Drasler, Bedia Begum Karakocak, Alke Petri-Fink, Giuseppe Valacchi, Marc Eeman and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2020 17:35

    Content type: Review

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  48. Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety r...

    Authors: Min Beom Heo, Minjeong Kwak, Kyu Sup An, Hye Jin Kim, Hyeon Yeol Ryu, So Min Lee, Kyung Seuk Song, In Young Kim, Ji-Hwan Kwon and Tae Geol Lee

    Citation: Particle and Fibre Toxicology 2020 17:34

    Content type: Research

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  49. In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make seve...

    Authors: Kevin E. Driscoll, Paul A. Borm, Ishrat Chaudhuri, Len Levy, Mei Yong, David Warheit, Robert McCunney and Günter Oberdörster

    Citation: Particle and Fibre Toxicology 2020 17:33

    Content type: Letter to the Editor

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  50. In response to the Letter to the Editor by Kevin Driscoll et al., we certainly agree that particle clearance halftimes are increased with increasing lung burden in rats, hamsters and mice, whereas complete inh...

    Authors: Anne T. Saber, Sarah S. Poulsen, Niels Hadrup, Nicklas R. Jacobsen and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2020 17:32

    Content type: Letter to the Editor

    Published on:

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