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Table 5 Mediators in BALF after exposure to MWCNT

From: Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

 

Study day 7

Study day 28

Concentration [mg/m3]

0.1

0.5

2.5

0.1

0.5

2.5

β2-Microglobulin

1.1

1.6**

2.8**

1.1

1.2

2.2**

CINC-1/IL-8

1.0

4.6**

13.3**

1.2

2.1*

10.5**

Clusterin

1.5

1.9*

4.4**

1.0

1.1

2.2*

GCP-2

0.9

8.1**

19.9**

1.6

4.0*

36.2**

KC/GROα

1.5

6.3*

36.9**

0.7

1.6

20.8**

MCP-1

1.0

2.3**

15.8**

1.5

1.6*

13.5**

MCP-3

1.0

2.5**

22.3**

1.6

1.7*

15.9**

M-CSF

1.4

4.3**

9.6**

1.1

1.7*

3.7**

MDC

1.2

6.1

50.8**

1.1

1.8

20.6**

MIP-1β

0.7

1.2

3.1**

1.6

1.5

4.1**

MIP-2

1.1

2.6**

4.5**

1.5

1.7*

5.4**

MPO

1.6

29.5*

193.3**

1.4

1.9

65.5**

VEGF

1.1

2.1*

5.0**

1.0

1.0

1.6

  1. * Statistically significant, p < 0.05; ** statistically significant, p < 0.01.
  2. Differences are expressed as x-fold ratios compared to the concurrent control group.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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