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Table 5 Mediators in BALF after exposure to MWCNT

From: Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

  Study day 7 Study day 28
Concentration [mg/m3] 0.1 0.5 2.5 0.1 0.5 2.5
β2-Microglobulin 1.1 1.6** 2.8** 1.1 1.2 2.2**
CINC-1/IL-8 1.0 4.6** 13.3** 1.2 2.1* 10.5**
Clusterin 1.5 1.9* 4.4** 1.0 1.1 2.2*
GCP-2 0.9 8.1** 19.9** 1.6 4.0* 36.2**
KC/GROα 1.5 6.3* 36.9** 0.7 1.6 20.8**
MCP-1 1.0 2.3** 15.8** 1.5 1.6* 13.5**
MCP-3 1.0 2.5** 22.3** 1.6 1.7* 15.9**
M-CSF 1.4 4.3** 9.6** 1.1 1.7* 3.7**
MDC 1.2 6.1 50.8** 1.1 1.8 20.6**
MIP-1β 0.7 1.2 3.1** 1.6 1.5 4.1**
MIP-2 1.1 2.6** 4.5** 1.5 1.7* 5.4**
MPO 1.6 29.5* 193.3** 1.4 1.9 65.5**
VEGF 1.1 2.1* 5.0** 1.0 1.0 1.6
  1. * Statistically significant, p < 0.05; ** statistically significant, p < 0.01.
  2. Differences are expressed as x-fold ratios compared to the concurrent control group.