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Table 1 Clearance T 1/2 of silver after 28 days of oral administration (superscript 0, 0-order; 1, 1st-order)

From: Biopersistence of silver nanoparticles in tissues from Sprague–Dawley rats

Tissue Male Female
  100 mg/kg/day 500 mg/kg/day 100 mg/kg/day 500 mg/kg/day
  Half life (days) R square Half life (days) R square Half life (days) R square Half life (days) R square
A. 10 nm
Blood0 76.88 0.47 98.94 0.58 77.33 0.47 78.14 0.48
Brain1 260.78 0.96 95.98 0.93 140.23 1.00 77.97 0.88
Kidneys1 29.75 0.94 69.81 0.91 79.60 0.71 77.49 0.89
Liver1 38.58 0.81 24.05 1.00 189.29 0.09 74.70 0.90
Spleen1 48.67 1.00 54.98 0.98 56.11 0.85 56.04 0.89
Testes/ovaries1 55.03 1.00 N/A N/A 34.79 0.95 35.77 0.92
B. 25 nm
Blood0 77.52 0.47 133.27 0.48 141.45 0.47 140.12 0.48
Brain1 136.03 0.77 81.06 0.96 124.08 1.00 60.05 0.90
Kidneys1 32.07 1.00 53.70 0.99 45.60 0.97 87.87 0.82
Liver0 70.10 0.70 62.94 0.82 60.72 0.66 68.29 0.49
Spleen1 30.93 0.99 164.91 0.74 66.32 0.93 66.97 0.94
Testes/ovaries1 64.59 1.00 N/A N/A 61.85 0.84 33.91 0.95
  1. N/A not applicable (Clearance T1/2 not obtainable).