Particle and Fibre Toxicology

Table 1 Clearance T _1/2 of silver after 28 days of oral administration (superscript 0, 0-order; 1, 1st-order)

From: Biopersistence of silver nanoparticles in tissues from Sprague–Dawley rats

Tissue	Male				Female
	100 mg/kg/day		500 mg/kg/day		100 mg/kg/day		500 mg/kg/day
	Half life (days)	R square	Half life (days)	R square	Half life (days)	R square	Half life (days)	R square
A. 10 nm
Blood⁰	76.88	0.47	98.94	0.58	77.33	0.47	78.14	0.48
Brain¹	260.78	0.96	95.98	0.93	140.23	1.00	77.97	0.88
Kidneys¹	29.75	0.94	69.81	0.91	79.60	0.71	77.49	0.89
Liver¹	38.58	0.81	24.05	1.00	189.29	0.09	74.70	0.90
Spleen¹	48.67	1.00	54.98	0.98	56.11	0.85	56.04	0.89
Testes/ovaries¹	55.03	1.00	N/A	N/A	34.79	0.95	35.77	0.92
B. 25 nm
Blood⁰	77.52	0.47	133.27	0.48	141.45	0.47	140.12	0.48
Brain¹	136.03	0.77	81.06	0.96	124.08	1.00	60.05	0.90
Kidneys¹	32.07	1.00	53.70	0.99	45.60	0.97	87.87	0.82
Liver⁰	70.10	0.70	62.94	0.82	60.72	0.66	68.29	0.49
Spleen¹	30.93	0.99	164.91	0.74	66.32	0.93	66.97	0.94
Testes/ovaries¹	64.59	1.00	N/A	N/A	61.85	0.84	33.91	0.95

N/A not applicable (Clearance T_1/2 not obtainable).

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ISSN: 1743-8977

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