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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells

Figure 6

Anakinra inhibits MM-induced cytokines in PLF of SCID mice. (A) at 1 wk, N = 3 samples/group; at 4 wks, N = 5–6 samples/group). * = significantly different (p ≤ 0.05) when compared to respective groups receiving no Anakinra; † = significantly different (p ≤ 0.05) when compared to respective saline (no tumor cell) groups. Left panels at 1 and 4 wks verify activity of Anakinra, an IL-1ra, in respective treatment groups. Use of a Bio-Plex panel for mouse cytokines on the same PLF samples failed to reveal any significant changes [12]. (B) Lack of changes in macrophages, neutrophils and lymphocyte numbers and proportions at 1 and 4 wks suggests the absence of involvement of cells of the immune system in cytokine release and inflammation. † = significantly different (p ≤ 0.05) when compared to respective saline (no Ana) groups.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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