Figure 11
From: Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
Effect of multi-walled carbon nanotube (MWCNT) inhalation on pulmonary pathology. Images are representative from mice exposed to the high dose (5 mg/m3 for 5 h/d for 19 d) and examined 84 d post-exposure. In the upper panels, MWCNT are within macrophages that have accumulated in connective tissue immediately below the thickened epithelium of the terminal bronchiole (TB). In comparison to the rest of the lung, general fibrosis, as identified by Trichrome staining, was scored as negative in MWCNT-treated mice (lower panels). No significant effects were scored for the middle and low dose exposures. The arrows in the left panels indicate the area of higher magnification shown in the respective right panel.