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Table 2 Changes in the hematological indices in all subjects exposed to DE and Filtered Air (FA)

From: A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Hematological indices

n

Change from baseline to 7 h Mean ± SE

DE effect Δ baseline - 7 h (95% CI)

n

Change from baseline to 22 h Mean ± SE

DE effect Δ baseline - 22 h (95% CI)

Filtered air

DE-200

Filtered air

DE-200

Leukocytes (x1000 cells/μL)

26

0.4 ± 0.2

0.4 ± 0.2

-0.0 (-0.3 to 0.3)

24

0.03 ± 0.1

0.1 ± 0.2

0.1 (-0.3 to 0.4)

Neutrophils (x1000 cells/μL)

24

0.4 ± 0.1

0.5 ± 0.2

0.0 (-0.4 to 0.4)

24

0.2 ± 0.1

0.2 ± 0.1

0.1 (-0.3 to 0.4)

Lymphocytes (x1000 cells/μL)

25

0.03 ± 0.1

-0.01 ± 0.1

-0.04 (-0.2 to 0.1)

23

-0.1 ± 0.05

-0.1 ± 0.04

-0.03 (-0.2 to 0.1)

Monocytes (x1000 cells/μL)

24

0.01 ± 0.02

-0.01 ± 0.03

-0.02 (-0.1 to 0.1)

21

-0.03 ± 0.02

-0.002 ± 0.04

0.03 (-0.1 to 0.1)

Erythrocytes (million cells/μL)

30

0.1 ± 0.02

-0.2 ± 0.2

-0.2 (-0.7 to 0.2)

28

0.1 ± 0.03

0.2 ± 0.3

0.1 (-0.5 to 0.7)

Platelets (x1000 cells/μL)

24

9.2 ± 3.4

11.4 ± 2.8

2.2 (-4.2 to 8.7)

22

4.5 ± 2.9

10.1± 2.6

5.5 (-2.8 to 13.8)

Hemoglobin (gm/dL)

24

0.2 ± 0.1

0.3 ± 0.1

0.2 (-0.0 to 0.4)

24

0.3 ± 0.1

0.5 ± 0.1

0.1 (-0.1 to 0.4)

Hematocrit (%)

26

0.5 ± 0.3

1.4 ± 0.2

1 (0.3 to 1.6)*

23

1.6 ± 0.4

1.1 ± 0.3

0.5 (-0.5 to 1.4)

  1. Data are shown for the absolute mean differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. DE effect refers to the effect attributable to DE calculated as [(Post –pre DE exposure - (Post-pre) FA exposure] displayed as the absolute change in each of the indices.
  2. *Indicates a P-value of 0.008; SE represents standard error; CI – Confidence Interval.