A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Table 3 Endothelial activation markers measured by the multiplex assay in subjects exposed to DE and FA

Endothelial biomarkers	N	Δ Baseline - 7 h Fold change ± SE (pg/dl)		DE Effect (Δ Baseline - 7 h) [fold change] (95% confidence interval)	N	Δ Baseline - 22 h Fold change ± SE (pg/dl)		DE Effect (Δ Baseline - 22 h) [fold change] (95% confidence interval)
Endothelial biomarkers	N	Filtered air	DE-200	P-values		Filtered air	DE-200	P-values
E-selectin	15	0.0 ± 0.1	0.02 ± 0.1	0.02 (95% CI: -0.3 to 0.3)	15	0.0 ± 0.1	0.1 ± 0.1	0.1 (95% CI: -0.2 to 0.4)
E-selectin	15	0.0 ± 0.1	0.02 ± 0.1	P=0.8	15	0.0 ± 0.1	0.1 ± 0.1	P=0.4
ICAM-1	15	0.0 ± 0.1	0.1 ± 0.1	0.2 (95% CI: -0.3 to 0.6)	17	0.04 ± 0.1	0.1 ± 0.1	0.1 (95% CI: -0.3 to 0.5)
ICAM-1	15	0.0 ± 0.1	0.1 ± 0.1	P=0.5	17	0.04 ± 0.1	0.1 ± 0.1	P=0.6
VCAM-1	15	0.02 ± 0.1	0.1 ± 0.1	0.03 (95% CI: -0.2 to 0.3)	17	-0.1± 0.1	0.1± 0.1	0.2 (95% CI: -0.1 to 0.4)
VCAM-1	15	0.02 ± 0.1	0.1 ± 0.1	P=0.8	17	-0.1± 0.1	0.1± 0.1	P=0.2

Data are shown for the mean log₂ differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. SE represents standard error. DE effect refers to the effect attributable to DE calculated as [(Post –pre DE exposure - (Post-pre) FA exposure] for the log₂ transformed values to obtain fold changes. Positive difference indicates that change in a given marker was relatively more positive over DE-exposure interval, as compared to change over FA exposure interval.

ISSN: 1743-8977