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Table 3 Endothelial activation markers measured by the multiplex assay in subjects exposed to DE and FA

From: A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Endothelial biomarkers N Δ Baseline - 7 h Fold change ± SE (pg/dl) DE Effect (Δ Baseline - 7 h) [fold change] (95% confidence interval) N Δ Baseline - 22 h Fold change ± SE (pg/dl) DE Effect (Δ Baseline - 22 h) [fold change] (95% confidence interval)
Filtered air DE-200 P-values   Filtered air DE-200 P-values
E-selectin 15 0.0 ± 0.1 0.02 ± 0.1 0.02 (95% CI: -0.3 to 0.3) 15 0.0 ± 0.1 0.1 ± 0.1 0.1 (95% CI: -0.2 to 0.4)
P=0.8 P=0.4
ICAM-1 15 0.0 ± 0.1 0.1 ± 0.1 0.2 (95% CI: -0.3 to 0.6) 17 0.04 ± 0.1 0.1 ± 0.1 0.1 (95% CI: -0.3 to 0.5)
P=0.5 P=0.6
VCAM-1 15 0.02 ± 0.1 0.1 ± 0.1 0.03 (95% CI: -0.2 to 0.3) 17 -0.1± 0.1 0.1± 0.1 0.2 (95% CI: -0.1 to 0.4)
P=0.8 P=0.2
  1. Data are shown for the mean log2 differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. SE represents standard error. DE effect refers to the effect attributable to DE calculated as [(Post –pre DE exposure - (Post-pre) FA exposure] for the log2 transformed values to obtain fold changes. Positive difference indicates that change in a given marker was relatively more positive over DE-exposure interval, as compared to change over FA exposure interval.