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Table 4 Inflammatory cytokines measured by the multiplex assay in humans exposed to DE and FA

From: A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Inflammatory cytokines N Δ Baseline -7 h [fold change ± SE] (pg/dL) DE Effect Δ Baseline-7 h [fold change] (95% confidence interval) N Δ Baseline -22 h [fold change ± SE] (pg/dL) DE Effect Δ Baseline-22 h [fold change] (95% confidence interval)
Filtered air DE-200 Filtered air DE-200
P-values P-values
Myeloperoxidase 16 0.2 ± 0.2 0.4 ± 0.3 0.2 16 0.01 ± 0.2 0.4 ± 0.2 0.4
(95% CI: -1.1 to 0.7) (95% CI: -0.2 to 0.9)
P=0.7 P=0.2
Adiponectin 16 0.1 ± 0.2 -0.02 ± 0.1 0.1 15 -0.1 ± 0.2 0.2 ± 0.1 0.3
(95% CI: -0.4 to 0.6) (95% CI: -0.3 to 0.8)
P=0.6 P=0.3
MMP-9 14 0.0 ± 0.1 0.3 ± 0.2 0.3 15 0.01 ± 0.1 -0.1 ± 0.1 -0.1
     (95% CI: -0.2 to 0.8)     (95% CI: -0.6 to 0.3)
     P=0.2     P=0.5
MCP-1 15 -0.2 ± 0.1 -0.2 ± 0.1 -0.01 15 -0.2 ± 0.1 -0.2 ± 0.1 -0.01
     (95% CI: -0.3 to 0.2)     (95% CI: -0.2 to 0.2)
     P=0.9     P=0.9
VEGF 15 0.1 ± 0.1 0.1 ± 0.1 0.02 16 0.1 ± 0.1 0.1 ± 0.1 0.01
(95% CI: -0.2 to 0.2) (95% CI: -0.1 to 0.1)
P=0.6 P=0.7
Pro-BNP 5 0.3 ± 0.2 -0.2 ± 0.3 -0.4 6 0.1 ± 0.3 -0.1 ± 0.3 -0.2
(95% CI: -1.5 to 0.7) (95% CI: -1.0 to 0.6)
P=0.9 P=0.1
TNF-α 15 -0.1 ± 0.04 -0.1 ± 0.1 0.02 15 0.0 ± 0.1 -0.03 ± 0.1 -0.03
     (95% CI: -1.4 to 0.2)     (95% CI: -0.2 to 0.1)
     P=0.8     P=0.5
IL-1β 9 -0.3 ± 0.2 0.1 ± 0.1 0.5 11 -0.2 ± 0.3 0.1 ± 0.3 0.3
     (95% CI: -0.01 to 1)     (95% CI: -1.1 to 2 )
     P=0.06     P=0.9
IL-6 11 -0.04 ± 0.1 1.1 ± 0.7 1.1 8 0.2 ± 0.1 -0.1 ± 0.1 -0.3
(95% CI: -0.7 to 3) (95% CI: -0.6 to 0.1)
P=0.6 P=0.1
IL-8 15 -0.3 ± 0.1 -0.2 ± 0.2 0.1 16 -0.2 ± 0.1 -0.3 ± 0.2 -0.1
(95% CI: -0.3 to 0.6) (95% CI: -0.5 to 0.3)
P=0.8 P=0.9
IL-10 15 -0.3 ± 0.1 -0.01 ± 0.1 0.3 16 -0.1 ± 0.1 0.1 ± 0.1 0.2
(95% CI: -0.1 to 0.6) (95% CI: -0.3 to 0.6)
P=0.2 P=0.5
  1. Data are shown for the mean log2 differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. DE effect refers to the effect attributable to DE calculated as (Post –pre DE exposure)-(Post-pre FA exposure) for the log2 transformed values to obtain fold changes. Positive difference indicates that the change in given marker was relatively more positive over DE-exposure interval, as compared to change over FA exposure interval. SE - Standard Error; CI - Confidence Interval.