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Table 4 Inflammatory cytokines measured by the multiplex assay in humans exposed to DE and FA

From: A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans

Inflammatory cytokines

N

Δ Baseline -7 h [fold change ± SE] (pg/dL)

DE Effect Δ Baseline-7 h [fold change] (95% confidence interval)

N

Δ Baseline -22 h [fold change ± SE] (pg/dL)

DE Effect Δ Baseline-22 h [fold change] (95% confidence interval)

Filtered air

DE-200

Filtered air

DE-200

P-values

P-values

Myeloperoxidase

16

0.2 ± 0.2

0.4 ± 0.3

0.2

16

0.01 ± 0.2

0.4 ± 0.2

0.4

(95% CI: -1.1 to 0.7)

(95% CI: -0.2 to 0.9)

P=0.7

P=0.2

Adiponectin

16

0.1 ± 0.2

-0.02 ± 0.1

0.1

15

-0.1 ± 0.2

0.2 ± 0.1

0.3

(95% CI: -0.4 to 0.6)

(95% CI: -0.3 to 0.8)

P=0.6

P=0.3

MMP-9

14

0.0 ± 0.1

0.3 ± 0.2

0.3

15

0.01 ± 0.1

-0.1 ± 0.1

-0.1

    

(95% CI: -0.2 to 0.8)

   

(95% CI: -0.6 to 0.3)

    

P=0.2

   

P=0.5

MCP-1

15

-0.2 ± 0.1

-0.2 ± 0.1

-0.01

15

-0.2 ± 0.1

-0.2 ± 0.1

-0.01

    

(95% CI: -0.3 to 0.2)

   

(95% CI: -0.2 to 0.2)

    

P=0.9

   

P=0.9

VEGF

15

0.1 ± 0.1

0.1 ± 0.1

0.02

16

0.1 ± 0.1

0.1 ± 0.1

0.01

(95% CI: -0.2 to 0.2)

(95% CI: -0.1 to 0.1)

P=0.6

P=0.7

Pro-BNP

5

0.3 ± 0.2

-0.2 ± 0.3

-0.4

6

0.1 ± 0.3

-0.1 ± 0.3

-0.2

(95% CI: -1.5 to 0.7)

(95% CI: -1.0 to 0.6)

P=0.9

P=0.1

TNF-α

15

-0.1 ± 0.04

-0.1 ± 0.1

0.02

15

0.0 ± 0.1

-0.03 ± 0.1

-0.03

    

(95% CI: -1.4 to 0.2)

   

(95% CI: -0.2 to 0.1)

    

P=0.8

   

P=0.5

IL-1β

9

-0.3 ± 0.2

0.1 ± 0.1

0.5

11

-0.2 ± 0.3

0.1 ± 0.3

0.3

    

(95% CI: -0.01 to 1)

   

(95% CI: -1.1 to 2 )

    

P=0.06

   

P=0.9

IL-6

11

-0.04 ± 0.1

1.1 ± 0.7

1.1

8

0.2 ± 0.1

-0.1 ± 0.1

-0.3

(95% CI: -0.7 to 3)

(95% CI: -0.6 to 0.1)

P=0.6

P=0.1

IL-8

15

-0.3 ± 0.1

-0.2 ± 0.2

0.1

16

-0.2 ± 0.1

-0.3 ± 0.2

-0.1

(95% CI: -0.3 to 0.6)

(95% CI: -0.5 to 0.3)

P=0.8

P=0.9

IL-10

15

-0.3 ± 0.1

-0.01 ± 0.1

0.3

16

-0.1 ± 0.1

0.1 ± 0.1

0.2

(95% CI: -0.1 to 0.6)

(95% CI: -0.3 to 0.6)

P=0.2

P=0.5

  1. Data are shown for the mean log2 differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. DE effect refers to the effect attributable to DE calculated as (Post –pre DE exposure)-(Post-pre FA exposure) for the log2 transformed values to obtain fold changes. Positive difference indicates that the change in given marker was relatively more positive over DE-exposure interval, as compared to change over FA exposure interval. SE - Standard Error; CI - Confidence Interval.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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