Figure 8

Qualitative histopathological evaluation and micrographs of lung tissues of mice exposed to ZnO NPs. Histopathologic evaluation (focusing on inflammation, cell injury, congestion, fibrosis and eosinophilia) was performed by light microscopy using a semi-quantitative 4-point scale: 0 - no lesion, 1 - minor focal change (<10% of lung), 2 – multifocal to coalescing inflammation (11-50%), and 3 – widespread > 50% (A). Micrographs of lung tissues showing most common minor changes: focal perivascular lymphoid cells (40x, B), focal accumulation of mononuclear cells (40x, C), and minor perivascular lymphoid cells (20x, D).