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Table 3 Total number of cells, total protein concentration and activity of LDH in BAL fluid in shams and ZnO NP-exposed mice (sub-acute study)

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

Sub-acute study

 

Experimental group:

Parameter in BAL fluid

Sentinels

Shams

ZnO

ZnO

(n = 2)

0 wk

0 wk

3 wks

 

(n = 6)

(n = 6)

(n = 6)

Total cells/mouse, n × 103

105.0 ± 27.0

92.7 ± 8.6

150.3 ± 14.9**

67.0 ± 11.2

Total protein, μg/mL

122.2 ± 2.9

135.5 ± 6.8

125.5 ± 4.1

131.3 ± 5.8

LDH activity, U/L

63 ± 18

46 ± 4

32 ± 9

93 ± 23**

  1. Values are expressed as mean and SE; **p < 0.01 significantly different from sham-exposed animals (one way ANOVA).