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Table 5 Total number of cells, total protein concentration and activity of LDH in BAL fluid and MDA concentration in the lungs in shams and ZnO NP-exposed mice (sub-chronic study)

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

Sub-chronic study

 

Experimental group:

Sentinels

Shams

ZnO

Shams

ZnO

0 wk

0 wk

3 wks

3 wks

Parameter in BAL fluid (n = 6):

    

Total cells/mouse, n × 103

137.3 ± 20.5

156.0 ± 11.8

302.0 ± 11.5***

116.3 ± 8.3

188.0 ± 19.3**

Total protein, μg/mL

101.7 ± 3.0

101.8 ± 2.4

108.4 ± 5.5

117.5 ± 16.2

123.8 ± 6.6

LDH activity, U/L

106.0 ± 19.5

60.8 ± 14.6

74.7 ± 12.7

95.3 ± 12.1

83.7 ± 14.5

Parameter in Lung (n = 6):

    

MDA concentration, nmol/mL

NA

50.0 ± 2.5

58.7 ± 6.8

NA

NA

  1. Values are expressed as mean and SE; ***p < 0.001, **p < 0.01 significantly different from control counterparts (one way ANOVA followed by Tukey test); NA not analyzed.