Table 5 Total number of cells, total protein concentration and activity of LDH in BAL fluid and MDA concentration in the lungs in shams and ZnO NP-exposed mice (sub-chronic study)
Sub-chronic study | Â | Experimental group: | |||
|---|---|---|---|---|---|
Sentinels | Shams | ZnO | Shams | ZnO | |
0 wk | 0 wk | 3 wks | 3 wks | ||
Parameter in BAL fluid (n = 6): |  |  |  |  | |
Total cells/mouse, n × 103 | 137.3 ± 20.5 | 156.0 ± 11.8 | 302.0 ± 11.5*** | 116.3 ± 8.3 | 188.0 ± 19.3** |
Total protein, μg/mL | 101.7 ± 3.0 | 101.8 ± 2.4 | 108.4 ± 5.5 | 117.5 ± 16.2 | 123.8 ± 6.6 |
LDH activity, U/L | 106.0 ± 19.5 | 60.8 ± 14.6 | 74.7 ± 12.7 | 95.3 ± 12.1 | 83.7 ± 14.5 |
Parameter in Lung (n = 6): |  |  |  |  | |
MDA concentration, nmol/mL | NA | 50.0 ± 2.5 | 58.7 ± 6.8 | NA | NA |