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Table 5 Total number of cells, total protein concentration and activity of LDH in BAL fluid and MDA concentration in the lungs in shams and ZnO NP-exposed mice (sub-chronic study)

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

Sub-chronic study   Experimental group:
Sentinels Shams ZnO Shams ZnO
0 wk 0 wk 3 wks 3 wks
Parameter in BAL fluid (n = 6):     
Total cells/mouse, n × 103 137.3 ± 20.5 156.0 ± 11.8 302.0 ± 11.5*** 116.3 ± 8.3 188.0 ± 19.3**
Total protein, μg/mL 101.7 ± 3.0 101.8 ± 2.4 108.4 ± 5.5 117.5 ± 16.2 123.8 ± 6.6
LDH activity, U/L 106.0 ± 19.5 60.8 ± 14.6 74.7 ± 12.7 95.3 ± 12.1 83.7 ± 14.5
Parameter in Lung (n = 6):     
MDA concentration, nmol/mL NA 50.0 ± 2.5 58.7 ± 6.8 NA NA
  1. Values are expressed as mean and SE; ***p < 0.001, **p < 0.01 significantly different from control counterparts (one way ANOVA followed by Tukey test); NA not analyzed.