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Table 6 Blood parameters in shams and mice after sub-chronic exposure to ZnO NPs

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

Whole blood parameter

 

Experimental group:

Sentinels

Shams 0 wk

ZnO 0 wk

ZnO 3 wks

WBC Ă— 103/ÎĽL

3.62 ± 0.5

4.18 ± 0.6

3.79 ± 1.0

4.90 ± 0.4

RBC Ă— 106/ÎĽL

9.66 ± 0.2

9.20 ± 0.2

9.6 ± 0.4

9.63 ± 0.3

Hemoglobin, g/dL

15.4 ± 0.2

16.0 ± 0.2

16.2 ± 0.4

16.2 ± 0.2

Hematocrit,%

50.2 ± 0.7

45.0 ± 0.6

47.8 ± 0.3

52.9 ± 1.7

Monocytes Ă— 103/ÎĽL

0.34 ± 0.1

0.22 ± 0.1

0.24 ± 0.1

0.20 ± 0.3

Neutrophils Ă— 103/ÎĽL

2.11 ± 0.5

0.92 ± 0.2

1.29 ± 0.3

1.9 ± 0.2

Lymphocytes Ă— 103/ÎĽL

1.14 ± 0.2

2.98 ± 0.4

2.20 ± 0.9

2.75 ± 0.4

Eosinophils Ă— 103/ÎĽL

0.032 ± 0.010

0.055 ± 0.013

0.062 ± 0.035

0.074 ± 0.013

Basophils Ă— 103/ÎĽL

0.002 ± 0.001

0.013 ± 0.003

0.013 ± 0.004

0.008 ± 0.003

  1. Values are expressed as mean and SE, WBC - white blood cells, RBC - red blood cells, n = 6 in each group.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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