Figure 4
From: Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials
Transmission electron microscopy of the spleen. A: control animal, magnification 8000×; B: animal exposed to 10 mg/m3 SiO2.acrylate, magnification 8000×. Image showing accumulation of large numbers of thrombocytes (arrows); C: animal exposed to 10 mg/m3 SiO2.acrylate, magnification 8000×. The lymphocytic cytoplasm is less homogenous than that of the control animal. D: magnification (25 000×) of an indicated sector of panel C, showing small electron-dense aggregates within the lymphocytic cytoplasm (arrows). E: Magnification (50 000×) of lymphocytic cytoplasm of the control animal having a very homogenous structure. F: Animal exposed to 10 mg/m3 SiO2.acrylate, magnification 200 000×. Again, the lymphocytic cytoplasm is less homogenous than that of the control animal, and electron-dense particles are found within the cytoplasm. By EDX analysis, the electron-dense particles were identified as being silicon-rich.