Table 2 Targeted and measured test substance concentrations and particle size distributions
From: Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials
Test substance | Targeted concentrations (mg/m3) | Measured concentrations, mean ± SD (mg/m3) | MMAD (μm)/GSD | Particle count concentration measured by SMPS (particle/cm3) | Particle count Median (μm) | |
|---|---|---|---|---|---|---|
Measurement 1 | Measurement 2 | |||||
Coated nano-TiO 2 | 0.5 | 0.6 ± 0.1 | 0.8/3.4 | 0.7/4.4 | 33905 | 0.131 |
2 | 2.0 ± 0.1 | 0.4/3.1 | 0.2/4.0 | 114889 | 0.153 | |
10 | 10.7 ± 1.2 | 0.4/3.0 | 0.4/3.6 | 205660 | 0.167 | |
Micron-scale ZnO | 12.5 | 15.3 ± 1.6 | 1.0/2.2 | 1.1/2.3 | 219031 | 0.167 |
Coated nano-ZnO (NM-111) | 0.5 | 0.6 ± 0.2 | 0.9/2.4 | 1.3/2.4 | 22126 | 0.144 |
2.5 | 2.8 ± 0.6 | 0.8/2.5 | 0.8/2.8 | 87044 | 0.177 | |
12.5 | 13.8 ± 2.0 | 0.8/2.4 | 0.9/2.4 | 159381 | 0.198 | |
SiO 2 .naked | 0.5 | 0.5 ± 0.1 | 1.3/3.0 | 1.7/3.4 | 20167 | 0.106 |
2.5 | 2.4 ± 0.1 | 1.0/2.3 | 1.2/2.2 | 47866 | 0.101 | |
10 | 10.4 ± 1.3 | 1.3/2.2 | 1.5/2.3 | 130972 | 0.127 | |
50 | 52.6 ± 4.3 | 2.0/2.8 | 2.2/2.6 | 172204 | 0.114 | |
SiO 2 .acrylate | 0.5 | 0.6 ± 0.1 | 1.1/ 2.4 | 1.2/2.3 | 13607 | 0.090 |
2.0 | 2.1 ± 0.2 | 1.0/2.3 | 1.0/2.3 | 30623 | 0.100 | |
10 | 9.7 ± 0.4 | 1.1/2.8 | 1.1/2.3 | 159381 | 0.110 | |
SiO 2 .PEG | 2 | 2.05 ± 0.12 | 1.0/2.8 | 1.0/2.5 | 17080 | 0.093 |
10 | 10.0 ± 1.4 | 1.0/2.7 | 1.1/2.7 | 73384 | 0.100 | |
50 | 54.1 ± 1.0 | 1.3/2.8 | 1.3/2.8 | 164639 | 0.125 | |
SiO 2 .phosphate | 2 | 2.9 ± 0.6 | 0.8/3.6 | 0.9/2.6 | 109566 | 0.09 |
10 | 10.0 ± 1.2 | 1.4/2.6 | 1.3/2.3 | 105863 | 0.09 | |
50 | 51.5 ± 5.4 | 1.4/2.5 | 1.6/2.4 | 308408 | 0.10 | |
SiO 2 .amino | 2 | 2.1 ± 0.4 | 0.8 /2.4 | 0.9/4.0 | 11036 | 0.09 |
10 | 10.2 ± 1.4 | 1.8/2.0 | 1.4/2.2 | 146680 | 0.10 | |
50 | 50.4 ± 3.7 | 1.7/2.7 | 1.3/2.8 | 282401 | 0.10 | |
Nano-BaSO 4 (NM-220) | 2 | 2.5 ± 0.3 | 1.3/2.4 | 1.2/2.2 | 71945 | 0.173 |
10 | 13.1 ± 0.7 | 1.5/2.1 | 1.4/2.3 | 245438 | 0.198 | |
50 | 53.4 ± 9.7 | 1.1/2.2 | 0.9/2.3 | 258642 | 0.188 | |
Nano-ZrO 2 | 0.5 | 0.5 ± 0.1 | 1.6/2.1 | 1.3/2.0 | 8580 | 0.091 |
2.5 | 2.6 ± 0.3 | 1.3/2.0 | 1.4/2.3 | 16024 | 0.138 | |
10 | 9.6 ± 1.2 | 1.8/2.2 | 2.0/1.8 | 76924 | 0.149 | |
ZrO 2 .TODA | 2 | 2.0 ± 0.1 | 1.3/4.0 | 1.2/3.9 | 59496 | 0.08 |
10 | 10.6 ± 0.3 | 1.0/4.7 | 1.1/4.2 | 72398 | 0.11 | |
50 | 52.2 ± 1.1 | 1.5/3.3 | 1.2/4.3 | 124267 | 0.13 | |
ZrO 2 .acrylate | 2 | 1.9 ± 0.1 | 0.6 /2.9 | 0.7/2.7 | 54218 | 0.06 |
10 | 10.1 ± 1.0 | 1.0/2.6 | 0.8/2.8 | 133269 | 0.06 | |
50 | 50.5 ± 4.7 | 1.4/2.7 | 1.3/3.4 | 166557 | 0.06 | |
Nano-CeO 2 | 0.5 | 0.8 ± 0.3 | 0.6/2.4 | 0.7/2.9 | 47745 | 0.111 |
2.5 | 3.0 ± 0.2 | 0.9/2.3 | 0.8/2.3 | 126354 | 0.144 | |
10 | 11.6 ± 0.5 | 0.8/2.5 | 0.7/2.4 | 458415 | 0.172 | |
Al-doped nano-CeO 2 | 0.5 | 0.6 ± 0.3 | 1.3/2.1 | 1.1/2.3 | 39695 | 0.252 |
2 | 2.1 ± 0.5 | 2.2/1.9 | 1.8/1.9 | - | - | |
10 | 9.2 ± 2.6 | 2.4/2.1 | 1.8/1.9 | 82383 | 0.200 | |