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Table 2 Targeted and measured test substance concentrations and particle size distributions

From: Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

Test substance Targeted concentrations (mg/m3) Measured concentrations, mean ± SD (mg/m3) MMAD (μm)/GSD Particle count concentration measured by SMPS (particle/cm3) Particle count Median (μm)
Measurement 1 Measurement 2
Coated nano-TiO 2 0.5 0.6 ± 0.1 0.8/3.4 0.7/4.4 33905 0.131
2 2.0 ± 0.1 0.4/3.1 0.2/4.0 114889 0.153
10 10.7 ± 1.2 0.4/3.0 0.4/3.6 205660 0.167
Micron-scale ZnO 12.5 15.3 ± 1.6 1.0/2.2 1.1/2.3 219031 0.167
Coated nano-ZnO (NM-111) 0.5 0.6 ± 0.2 0.9/2.4 1.3/2.4 22126 0.144
2.5 2.8 ± 0.6 0.8/2.5 0.8/2.8 87044 0.177
12.5 13.8 ± 2.0 0.8/2.4 0.9/2.4 159381 0.198
SiO 2 .naked 0.5 0.5 ± 0.1 1.3/3.0 1.7/3.4 20167 0.106
2.5 2.4 ± 0.1 1.0/2.3 1.2/2.2 47866 0.101
10 10.4 ± 1.3 1.3/2.2 1.5/2.3 130972 0.127
50 52.6 ± 4.3 2.0/2.8 2.2/2.6 172204 0.114
SiO 2 .acrylate 0.5 0.6 ± 0.1 1.1/ 2.4 1.2/2.3 13607 0.090
2.0 2.1 ± 0.2 1.0/2.3 1.0/2.3 30623 0.100
10 9.7 ± 0.4 1.1/2.8 1.1/2.3 159381 0.110
SiO 2 .PEG 2 2.05 ± 0.12 1.0/2.8 1.0/2.5 17080 0.093
10 10.0 ± 1.4 1.0/2.7 1.1/2.7 73384 0.100
50 54.1 ± 1.0 1.3/2.8 1.3/2.8 164639 0.125
SiO 2 .phosphate 2 2.9 ± 0.6 0.8/3.6 0.9/2.6 109566 0.09
10 10.0 ± 1.2 1.4/2.6 1.3/2.3 105863 0.09
50 51.5 ± 5.4 1.4/2.5 1.6/2.4 308408 0.10
SiO 2 .amino 2 2.1 ± 0.4 0.8 /2.4 0.9/4.0 11036 0.09
10 10.2 ± 1.4 1.8/2.0 1.4/2.2 146680 0.10
50 50.4 ± 3.7 1.7/2.7 1.3/2.8 282401 0.10
Nano-BaSO 4 (NM-220) 2 2.5 ± 0.3 1.3/2.4 1.2/2.2 71945 0.173
10 13.1 ± 0.7 1.5/2.1 1.4/2.3 245438 0.198
50 53.4 ± 9.7 1.1/2.2 0.9/2.3 258642 0.188
Nano-ZrO 2 0.5 0.5 ± 0.1 1.6/2.1 1.3/2.0 8580 0.091
2.5 2.6 ± 0.3 1.3/2.0 1.4/2.3 16024 0.138
10 9.6 ± 1.2 1.8/2.2 2.0/1.8 76924 0.149
ZrO 2 .TODA 2 2.0 ± 0.1 1.3/4.0 1.2/3.9 59496 0.08
10 10.6 ± 0.3 1.0/4.7 1.1/4.2 72398 0.11
50 52.2 ± 1.1 1.5/3.3 1.2/4.3 124267 0.13
ZrO 2 .acrylate 2 1.9 ± 0.1 0.6 /2.9 0.7/2.7 54218 0.06
10 10.1 ± 1.0 1.0/2.6 0.8/2.8 133269 0.06
50 50.5 ± 4.7 1.4/2.7 1.3/3.4 166557 0.06
Nano-CeO 2 0.5 0.8 ± 0.3 0.6/2.4 0.7/2.9 47745 0.111
2.5 3.0 ± 0.2 0.9/2.3 0.8/2.3 126354 0.144
10 11.6 ± 0.5 0.8/2.5 0.7/2.4 458415 0.172
Al-doped nano-CeO 2 0.5 0.6 ± 0.3 1.3/2.1 1.1/2.3 39695 0.252
2 2.1 ± 0.5 2.2/1.9 1.8/1.9 - -
10 9.2 ± 2.6 2.4/2.1 1.8/1.9 82383 0.200