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Table 2 Sizes of TiO 2 NP and vesicles, distance of TiO 2 NP to vesicle membrane

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Genotype

NNP

dV, nm

dNP, nm

RV/P

DNP-M, nm

Cftr mutant

     

  Epithelium, type 2 cells

5

    

  Mean ± SD

 

245 ± 92

37.7 ± 20.3

5.5 ± 1.4

47.6 ± 8.4

  Range

 

168 - 347

22.6 – 66.2

4.2 – 7.0

36 - 56

  Macrophages

14

    

  Mean ± SD

 

409 ± 327

36.7 ± 11.5

11.6 ± 10.8

28.2* ± 38.2

  Range

 

101 - 1247

20.7 – 59.7

2.6 – 37.8

7 - 156

WT

     

  Epithelium

0

    

  Macrophages

18

    

  Mean ± SD

 

450 ± 256

40.7 ± 13.9

9.2 ± 4.6

58.1 ± 76.2

  Range

 

183 - 857

27.4 – 86.0

2.8 – 17.1

11 - 267

  1. NNP: Number of TiO2NP, dV: vesicle diameter, dNP: NP diameter, dNP-M: distance of NP to vesicle membrane, RV/P: ratio of vesicle to particle size, *: significant difference to WT mice, p < 0.05, n = 2 per genotype.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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