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Table 2 Sizes of TiO 2 NP and vesicles, distance of TiO 2 NP to vesicle membrane

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Genotype NNP dV, nm dNP, nm RV/P DNP-M, nm
Cftr mutant      
  Epithelium, type 2 cells 5     
  Mean ± SD   245 ± 92 37.7 ± 20.3 5.5 ± 1.4 47.6 ± 8.4
  Range   168 - 347 22.6 – 66.2 4.2 – 7.0 36 - 56
  Macrophages 14     
  Mean ± SD   409 ± 327 36.7 ± 11.5 11.6 ± 10.8 28.2* ± 38.2
  Range   101 - 1247 20.7 – 59.7 2.6 – 37.8 7 - 156
WT      
  Epithelium 0     
  Macrophages 18     
  Mean ± SD   450 ± 256 40.7 ± 13.9 9.2 ± 4.6 58.1 ± 76.2
  Range   183 - 857 27.4 – 86.0 2.8 – 17.1 11 - 267
  1. NNP: Number of TiO2NP, dV: vesicle diameter, dNP: NP diameter, dNP-M: distance of NP to vesicle membrane, RV/P: ratio of vesicle to particle size, *: significant difference to WT mice, p < 0.05, n = 2 per genotype.