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Table 3 BAL cytokines

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

A)   Cytokines (MultiPlex assay)
Genotype Treatment IL-1a IL-6 IL-12(p40) IL-12(p70) G-CSF CXCL1 CCL3 CCL5  
   pg/mL ± pg/mL ± pg/mL ± pg/mL ± pg/mL ± pg/mL ± pg/mL ± pg/mL ±
WT CC 3.5 0.2 5.7 - 1.4 - 4.0 - 1.2 - 2.5 0.2 49.3 - 1.6 -
Sham 7.7 2.4 5.4 0.3 2.3 0.3 4.3 0.2 1.5 0.3 5.6 2.5 100.1 28.6 3.8 1.3
CNP d1 6.4 0.8 54.4 9.1 4.5 1.5 4.2 0.2 105.5 30.6 104.4 21.3 103.7 20.1 2.4 0.3
CNP d3 4.2 0.5 5.7 - 11.1 8.1 4.0 - 9.4 3.6 10.7 4.0 66.2 12.7 12.7 6.4
CNP d7 4.9 0.5 5.7 - 4.2 1.1 4.0 - 1.3 0.1 8.6 2.5 100.9 17.2 9.0 4.0
Cftr mutant CC 6.9 0.6 5.7 - 2.6 0.3 4.0 - 1.2 - 3.6 0.4 101.4 6.6 5.1 0.5
Sham 7.7 0.8 5.7 - 3.2 0.3 3.7 0.3 1.2 - 2.9 0.3 79.5 15.0 3.2 0.7
CNP d1 11.7* 3.7 95.3 29.8 6.0 1.3 4.5 0.2 156.1 59.0 92.4 24.0 129.7 22.2 2.8 0.4
CNP d3 4.2 0.6 14.0 5.3 15.4 4.6 4.7 0.6 125.3* 73.5 8.6 1.0 99.6 18.3 35.4* 16.3
  CNP d7 4.0 0.5 5.7 - 7.2 1.8 3.9 0.2 1.2 - 13.8 1.7 93.2 28.9 11.6 3.8
B)   Cytokines (ELISA assay)         
Genotype Treatment CXCL5 LCN2 GAL3 OPN         
   pg/mL ± ng/mL ± ng/mL ± ng/mL ±         
WT CC 70.0 14.7 20.9 1.3 7.0 4.4 5.9 0.6         
Sham 22.5 2.0 22.4 1.4 14.1 0.8 4.7 1.0         
CNP d1 423.7 70.6 226.0 36.5 18.8 2.9 12.3 2.8         
CNP d3 145.7 51.2 101.8 15.6 13.1 3.1 20.3 8.9         
CNP d7 241.1 26.0 63.9 16.2 12.2 1.0 21.2 3.1         
Cftr mutant CC 49.2 4.2 12.3 1.4 23.8* 2.4 5.8 2.0         
Sham 25.1 3.4 8.7 7.2 13.9 0.9 6.3 1.9         
CNP d1 413.5 55.6 163.7 32.6 19.0 3.2 13.8 1.6         
CNP d3 252.5* 31.5 181.6* 31.6 17.9 2.3 46.2* 4.8         
CNP d7 207.4 50.1 72.0 11.1 10.1 3.1 25.9 2.8         
  1. Mean ± SD, *: significant difference to corresponding value in WT mice, p < 0.05, CC: cage control (untreated animals), Sham: instilled with 50 μL pyrogen-free distilled water.