Particle and Fibre Toxicology

Table 3 BAL cytokines

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

A)		Cytokines (MultiPlex assay)
Genotype	Treatment	IL-1a		IL-6		IL-12(p40)		IL-12(p70)		G-CSF		CXCL1		CCL3		CCL5
		pg/mL	±	pg/mL	±	pg/mL	±	pg/mL	±	pg/mL	±	pg/mL	±	pg/mL	±	pg/mL	±
WT	CC	3.5	0.2	5.7	-	1.4	-	4.0	-	1.2	-	2.5	0.2	49.3	-	1.6	-
	Sham	7.7	2.4	5.4	0.3	2.3	0.3	4.3	0.2	1.5	0.3	5.6	2.5	100.1	28.6	3.8	1.3
	CNP d1	6.4	0.8	54.4	9.1	4.5	1.5	4.2	0.2	105.5	30.6	104.4	21.3	103.7	20.1	2.4	0.3
	CNP d3	4.2	0.5	5.7	-	11.1	8.1	4.0	-	9.4	3.6	10.7	4.0	66.2	12.7	12.7	6.4
	CNP d7	4.9	0.5	5.7	-	4.2	1.1	4.0	-	1.3	0.1	8.6	2.5	100.9	17.2	9.0	4.0
*Cftr* mutant	CC	6.9	0.6	5.7	-	2.6	0.3	4.0	-	1.2	-	3.6	0.4	101.4	6.6	5.1	0.5
	Sham	7.7	0.8	5.7	-	3.2	0.3	3.7	0.3	1.2	-	2.9	0.3	79.5	15.0	3.2	0.7
	CNP d1	11.7*	3.7	95.3	29.8	6.0	1.3	4.5	0.2	156.1	59.0	92.4	24.0	129.7	22.2	2.8	0.4
	CNP d3	4.2	0.6	14.0	5.3	15.4	4.6	4.7	0.6	125.3*	73.5	8.6	1.0	99.6	18.3	35.4*	16.3
	CNP d7	4.0	0.5	5.7	-	7.2	1.8	3.9	0.2	1.2	-	13.8	1.7	93.2	28.9	11.6	3.8
B)		Cytokines (ELISA assay)
Genotype	Treatment	CXCL5		LCN2		GAL3		OPN
		pg/mL	±	ng/mL	±	ng/mL	±	ng/mL	±
WT	CC	70.0	14.7	20.9	1.3	7.0	4.4	5.9	0.6
	Sham	22.5	2.0	22.4	1.4	14.1	0.8	4.7	1.0
	CNP d1	423.7	70.6	226.0	36.5	18.8	2.9	12.3	2.8
	CNP d3	145.7	51.2	101.8	15.6	13.1	3.1	20.3	8.9
	CNP d7	241.1	26.0	63.9	16.2	12.2	1.0	21.2	3.1
*Cftr* mutant	CC	49.2	4.2	12.3	1.4	23.8*	2.4	5.8	2.0
	Sham	25.1	3.4	8.7	7.2	13.9	0.9	6.3	1.9
	CNP d1	413.5	55.6	163.7	32.6	19.0	3.2	13.8	1.6
	CNP d3	252.5*	31.5	181.6*	31.6	17.9	2.3	46.2*	4.8
	CNP d7	207.4	50.1	72.0	11.1	10.1	3.1	25.9	2.8

Mean ± SD, *: significant difference to corresponding value in WT mice, p < 0.05, CC: cage control (untreated animals), Sham: instilled with 50 μL pyrogen-free distilled water.

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