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Figure 7 | Particle and Fibre Toxicology

Figure 7

From: Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation

Figure 7

Role of ROS and antioxidants in asbestos-induced activation of the NLRP3 inflammasome. A simplified schema showing how increased ROS or decreased GSH as a result of asbestos exposure can cause oxidation of Trx1 and release of TXNIP. TXNIP thus released binds to NLRP3 and activates it as represented by caspase-1 activation. NAC on the other hand reduces ROS and elevates GSH levels resulting in inhibition of activation of NLRP3.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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