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Table 6 Schematic overview of the design of the toxicokinetic study for determination of tissue distribution of titaniumdioxide nanomaterials

From: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Material Daily dose (mg TiO2/animal) # daily doses Route Autopsy
     Day 2 Day 6 Day 14 Day 30 Day 90
NM* 2.3 1 IV 3 M + 3 F - - - 3 M + 3 F
NM* 2.3 5 IV - 3 M + 3 F 3 M 3 M 3 M + 3 F
NM* 2.3 1 Oral 3 M     
NM* 2.3 5 Oral - 3 M + 3 F** - - -
Vehicle - 1 or 5 IV 2 M + 1 F 2 M + 1 F - - 2 M + 1 F
Vehicle - 1 or 5 Oral 2 M + 1 F 2 M + 1 F - - 2 M + 1 F
  1. *NM is NM-100, NM-102, NM-103 or NM-104 for the IV route and NM-101, NM-102, NM-103, or NM-104 for the oral route.
  2. **female animals for NM-101 only.