Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Table 6 Schematic overview of the design of the toxicokinetic study for determination of tissue distribution of titaniumdioxide nanomaterials

Material	Daily dose (mg TiO₂/animal)	# daily doses	Route	Autopsy
				Day 2	Day 6	Day 14	Day 30	Day 90
NM*	2.3	1	IV	3 M + 3 F	-	-	-	3 M + 3 F
NM*	2.3	5	IV	-	3 M + 3 F	3 M	3 M	3 M + 3 F
NM*	2.3	1	Oral	3 M
NM*	2.3	5	Oral	-	3 M + 3 F**	-	-	-
Vehicle	-	1 or 5	IV	2 M + 1 F	2 M + 1 F	-	-	2 M + 1 F
Vehicle	-	1 or 5	Oral	2 M + 1 F	2 M + 1 F	-	-	2 M + 1 F

*NM is NM-100, NM-102, NM-103 or NM-104 for the IV route and NM-101, NM-102, NM-103, or NM-104 for the oral route.
**female animals for NM-101 only.

ISSN: 1743-8977