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Table 1 Intended and actual silica exposure doses

From: Sub-chronic toxicity study in rats orally exposed to nanostructured silica

Group Intended total silica exposure dose (mg/kg bw/day)   Actual exposure dose  
Total silica (mg/kg bw/day) Added silicaa(mg/kg/bw/day) Silica in nano-size rangeb(mg/kg bw/day)
SAS low 100 222 83 33
SAS medium 1000 942 819 328
SAS high 2500 2142 2047 819
NM-202 low 100 221 82 82
NM-202 medium 500 537 405 405
NM-202 high 1000 933 810 810
Negative control 0 133 0 <21
  1. The actual exposure doses were calculated from the (HDC) ICP-MS silicon measurements in the feed mixture (0.95 ± 0.19 mg silica/g), standard feed pellets (1.8 ± 0.9 mg silica/g), and drinking water (0.019 ± 0.003 mg silica/g). Exposure to silica originating from consumption of standard feed pellets and drinking water was based on an average feed intake of 27 g/day and an average water intake of 45 ml/day at an average body weight of 350 g [22] (for a more detailed calculation, see Additional file 1: Table S1). aTotal silica (mg/kg bw/day) – (dose of silica from the standard diet + drinking water in mg/kg bw/day) = dose of added silica (i.e. SAS or NM-202 in mg/kg bw/day). bWith a size of 5 – 200 nm.