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Table 1 Effect of Exposure to UFCB vs. FCB (High Dose) on pulmonary responses.

From: Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide

Parameter Group 1 day 7 days 42 days
PMN (106) Control 1.5 ± 0.2 1.1 ± 0.1 1.0 ± 0.1
  UFCB high 22.1 ± 0.8* 8.1 ± 0.3* 4.2 ± 0.7*
  FCB high 15.5 ± 0.4* 5.7 ± 0.2* 3.3 ± 0.2*
LDH (U/l) Control 49.3 ± 1.4 43.8 ± 0.8 45.1 ± 1.7
  UFCB high 179.1 ± 6* 116.3 ± 4* 84.6 ± 2*
  FCB high 135.3 ± 6* 88.6 ± 2* 71.9 ± 1*
Albumin (mg/ml) Control 0.21 ± 0.1 0.12 ± 0.01 0.18 ± 0.02
  UFCB high 0.48 ± 0.02* 0.31 ± 0.025* 0.32 ± 0.01*
  FCB high 0.40 ± 0.01* 0.25 ± 0.01* 0.26 ± 0.01*
TNF-α (pg/ml) Control 24.8 ± 0.5 28.2 ± 0.6 32.2 ± 0.6
  UFCB high 45.3 ± 2* 50.4 ± 1* 60.1 ± 1*
  FCB high 30.9 ± 0.8 34.3 ± 1 38.6 ± 0.9
MIP-2 (pg/ml) Control 437.7 ± 14 497.2 ± 22 476.5 ± 22
  UFCB high 544.1 ± 34* 727.8 ± 29* 615.2 ± 21*
  FCB high 384.9 ± 22 485.8 ± 22 532.9 ± 22
IL-1β (pg/ml) Control 58.1 ± 4 69.7 ± 5 70.5 ± 7
  UFCB high 184.9 ± 10* 213.6 ± 8* 262.8 ± 9*
  FCB high 78.6 ± 6 83.7 ± 9 115.7 ± 12
Zym. Stim. Chemi. Control 3.14 ± .08 3.06 ± .09 3.22 ± .30
  UFCB high 7.28 ± .13* 5.35 ± .12* 3.85 ± .55
  FCB high 4.48 ± .10* 4.06 ± .04* 2.96 ± 41
NO Dep. Chemi. Control 0.68 ± .05 0.52 ± .06 0.49 ± .07
  UFCB high 4.2 ± .06* 3.6 ± .05* 2.4 ± .40*
  FCB high 4.0 ± .04* 1.7 ± .05* 1.3 ± .04
  1. * denotes that the change from control is statistically significant (p < 0.05) using ANOVA.