From: Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice
 |  | C57 | C57 | ApoE -/- | ApoE -/- |
---|---|---|---|---|---|
 |  | Control | CB 54 μg | Control | CB 54 μg |
3 h | Â | Â | Â | Â | Â |
lung tissue | Mip-2 | 9.6 ± 2.5 | 20.4 ± 5.9 | 10.2 ± 3.2 | 108.1 ± 15.1*** |
 | Mcp-1 | 12.1 ± 4.6 | 20.6 ± 5.4 | 10.1 ± 1.2 | 265.5 ± 163.9*** |
 | Il-6 | 4.0 ± 1.9 | 5.8 ± 2.3 | 2.1 ± 0.4 | 31.4 ± 4.8*** |
BAL | Neutrophils% a | 3.4 ± 2.4 | 4.5 ± 0.4 | 3.7 ± 1.2 | 13.8 ± 10.9 |
 | Macrophages% a | 94.5 ± 2.6 | 93.8 ± 0.4 | 93.9 ± 2.0 | 83.1 ± 10.7 |
 | Total BAL cells | 55732 ± 14617 | 73407 ± 9267 | 83262 ± 4819 | 49417 ± 7700 |
 | Protein | 133.3 ± 21.7 | 82.4 ± 6.0* | 102.5 ± 5.2 | 139.3 ± 17.3** |
24 h | Â | Â | Â | Â | Â |
lung tissue | Mip-2 | 7.8 ± 1.0 | 82.8 ± 24.8*** | 5.1 ± 0.5 | 134.8 ± 33.2*** |
 | Mcp-1 | 39.1 ± 10.4 | 434.1 ± 145.8*** | 28.3 ± 2.7 | 1087.0 ± 310.6*** |
 | Il-6 | 2.1 ± 0.6 | 20.3 ± 12.3* | 1.1 ± 0.1 | 44.0 ± 13.0*** |
BAL | Neutrophils% a | 5.2 ± 1.2 | 51.0 ± 12.6** | 5.3 ± 1.6 | 75.8 ± 3.4*** |
 | Macrophages% a | 92.6 ± 2.3 | 47.9 ± 12.7** | 93.6 ± 1.5 | 22.1 ± 3.7*** |
 | Total BAL cells | 49022 ± 3589 | 98857 ± 11618 | 65290 ± 5246 | 78596 ± 21414 |
 | Protein | 114.5 ± 13.7 | 124.7 ± 10.6 | 110.6 ± 5.7 | 182.4 ± 7.1*** |