From: Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice
 |  | Control | Au 0.54 μg | C 60 54 μg | SWCNT 54 μg | CB 54 μg | significant dose-related differences b |
---|---|---|---|---|---|---|---|
3 h | Â | Â | Â | Â | Â | Â | Â |
lung tissue | Mip-2 | 10.2 ± 3.2 | 34.0 ± 17.1* | 10.9 ± 2.0 | 1170.9 ± 530.1*** | 108.1 ± 15.1*** | SWCNT ≈ CB>Au>C60 |
 | Mcp-1 | 10.1 ± 1.2 | 20.4 ± 3.4*** | 20.4 ± 2.1*** | 526.7 ± 214.8*** | 265.5 ± 163.9*** | SWCNT ≈ CB>>>C60 ≈ Au |
 | Il-6 | 2.1 ± 0.4 | 2.7 ± 0.7 | 1.7 ± 0.2 | 411.5 ± 180.6*** | 31.4 ± 4.8*** | SWCNT>>>CB>>>Au ≈ C60 |
BAL | Neutrophils % a | 3.7 ± 1.2 | 5.5 ± 2.6 | 2.8 ± 0.7 | 19.1 ± 8.9 | 13.8 ± 10.9 | SWCNT ≈ CB ≈ Au ≈ C60 |
 | Macrophages % a | 93.9 ± 2.0 | 93.8 ± 2.5 | 96.9 ± 0.7 | 78.8 ± 9.0 | 83.1 ± 10.7 | SWCNT ≈ CB ≈ Au ≈ C60 |
 | Total BAL cells | 83262 ± 4819 | 65081 ± 8276 | 68929 ± 3849 | 55426 ± 16930 | 49417 ± 7700 |  |
 | Comet %T | 9.6 ± 0.6 | 11.6 ± 0.9 | 12.1 ± 0.9 | 13.4 ± 1.3** | 14.4 ± 1.6** | CB ≈ SWCNT>>C60 ≈ Au |
 | Protein μg/ml | 102.5 ± 5.2 | 105.2 ± 6.2 | 77.4 ± 2.9** | 171.8 ± 22.2*** | 139.3 ± 17.3** | SWCNT ≈ CB>Au>>C60 |
24 h | Â | Â | Â | Â | Â | Â | Â |
lung tissue | Mip-2 | 5.1 ± 0.5 | 8.3 ± 1.7 | 31.0 ± 12.8*** | 34.4 ± 9.0*** | 134.8 ± 33.2*** | CB>SWCNT ≈ C60>>Au |
 | Mcp-1 | 28.3 ± 2.7 | 34.6 ± 8.5 | 116.0 ± 22.8*** | 372.7 ± 110.2*** | 1087.0 ± 310.6*** | CB ≈ SWCNT>>C60>>>Au |
 | Il-6 | 1.1 ± 0.1 | 2.0 ± 0.5 | 5.6 ± 1.1*** | 32.5 ± 9.9*** | 44.0 ± 13.0*** | CB ≈ SWCNT>>C60>>Au |
BAL | Neutrophils % a | 5.3 ± 1.6 | 4.2 ± 3.1 | 6.4 ± 4.2 | 64.7 ± 7.1*** | 75.8 ± 3.4*** | CB ≈ SWCNT>>>C60 ≈ Au |
 | Macrophages % a | 93.6 ± 1.5 | 94.7 ± 3.6 | 93.1 ± 4.2 | 28.6 ± 4.9*** | 22.1 ± 3.7*** | CB ≈ SWCNT>>>C60 ≈ Au |
 | Total BAL cells | 65290 ± 5246 | 67881 ± 6667 | 76008 ± 7420 | 61643 ± 19999 | 78596 ± 21414 |  |
 | Protein μg/ml | 110.6 ± 5.7 | 109.5 ± 5.2 | 83.6 ± 7.8*** | 288.8 ± 21.3*** | 182.4 ± 7.1*** | SWCNT>>>CB>>>Au>>>C60 |