Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Table 5 Experimental setup; including exposure, exposure dose, time of sacrifice and the number and strain of mice.

Exposure	Vehicle Instillation		Au 0.54 μg Instillation		C₆₀ 54 μg Instillation		SWCNT 54 μg Instillation		CB 54 μg Instillation		CB 18 μg Instillation
Time of sacrifice	3 h	24 h	3 h	24 h	3 h	24 h	3 h	24 h	3 h	24 h		24 h
# of C57 mice	7 ¹	7 ¹							7 ¹	7 ¹
# of ApoE ^-/- mice	15 ^1,2,3	15 ^1,2,3	7 ³	7 ³	7 ³	7 ³	7 ³	7 ³	7 ^1,2,3	7^1,2,3		5 ²
Exposure	Vehicle Instillation		QD620 63 μg Cd Instillation		QD621 63 μg Cd Instillation		HEPA inhalation 30 or 90 min		CB inhalation 60 mg/m ³ 30 min		CB inhalation 60 mg/m ³ 90 min
Time of sacrifice	3 h	24 h	3 h	24 h	3 h	24 h		24 h		24 h		24 h
# of ApoE ^-/- mice	5 ⁴	5 ⁴	5 ⁴	5 ⁴	5 ⁴	5 ⁴		10 ²		5 ²		5 ²

All mice received exposure via instillation unless otherwise is stated in the table.
^1,2,3,4 Indicate the study part(s) the animals were included in (see design in Material and Methods section).

ISSN: 1743-8977