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Table 1 Relative organ weights for male rats after 90-day oral administration of silver nanoparticles (mean ± S.D., n≥9)

From: Subchronic oral toxicity of silver nanoparticles

  Dose (mg/Kg)
  0 30 125 500
Testis (Left) 0.47 ± 0.02 0.48 ± 0.03 0.49 ± 0.02 0.51 ± 0.01*
Testis (Right) 0.47 ± 0.02 0.48 ± 0.02 0.48 ± 0.02 0.49 ± 0.02
Spleen 0.21 ± 0.03 0.21 ± 0.01 0.22 ± 0.01 0.20 ± 0.02
Liver 2.96 ± 0.10 2.91 ± 0.16 2.92 ± 0.09 2.87 ± 0.11
Pituitary gland 0.002 ± 0.001 0.003 ± 0.001 0.005 ± 0.006 0.004 ± 0.003
Adrenal gland (Left) 0.011 ± 0.006 0.007 ± 0.002 0.008 ± 0.001 0.009 ± 0.003
Adrenal gland (Right) 0.008 ± 0.001 0.007 ± 0.001 0.008 ± 0.001 0.009 ± 0.002
Prostate 0.13 ± 0.06 0.16 ± 0.05 0.15 ± 0.04 0.16 ± 0.05
Lungs 0.42 ± 0.02 0.41 ± 0.04 0.42 ± 0.03 0.43 ± 0.03
Brain 0.62 ± 0.02 0.61 ± 0.03 0.62 ± 0.02 0.63 ± 0.02
Heart 0.27 ± 0.02 0.26 ± 0.02 0.27 ± 0.01 0.26 ± 0.02
Thymus 0.10 ± 0.02 0.10 ± 0.02 0.11 ± 0.02 0.10 ± 0.02
Kidney (Left) 0.28 ± 0.01 0.28 ± 0.02 0.29 ± 0.01 0.28 ± 0.01
Kidney (Right) 0.29 ± 0.02 0.28 ± 0.02 0.29 ± 0.01 0.29 ± 0.01
  1. *Significant difference vs. control, p < 0.05