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Table 3 Serum values for male rats after 90-day oral administration of silver nanoparticles (mean ± S.D.)

From: Subchronic oral toxicity of silver nanoparticles

 

Dose (mg/Kg)

 

0 (n = 10)

30 (n = 10)

125 (n = 10)

500 (n = 10)

ALB

2.92 ± 0.26

2.82 ± 0.13

2.79 ± 0.10

2.86 ± 0.10

ALP

291.60 ± 35.40

279.50 ± 48.78

306.40 ± 35.16

343.80 ± 65.67

CA

10.93 ± 0.59

10.77 ± 0.67

10.49 ± 0.22

10.60 ± 0.24

CHO

88.50 ± 8.45

94.80 ± 7.54

98.30 ± 5.46**

106.00 ± 6.38**

CRE

0.91 ± 0.10

0.86 ± 0.11

0.85 ± 0.05

0.83 ± 0.15

GGT

0.40 ± 0.52

0.10 ± 0.32

0.40 ± 0.52

0.50 ± 0.53

GLU

168.20 ± 24.36

193.50 ± 42.15

165.40 ± 17.66

177.70 ± 20.89

AST

105.00 ± 27.01

97.10 ± 22.71

85.00 ± 12.35

98.20 ± 35.64

ALT

72.10 ± 5.17

77.20 ± 8.39

68.70 ± 4.64

71.40 ± 20.03

LDH

1230.80 ± 1351.96

784.80 ± 675.03

598.70 ± 351.37

644.20 ± 400.41

MG

2.27 ± 0.33

2.36 ± 0.62

2.06 ± 0.10

2.19 ± 0.09

TP

6.61 ± 0.21

6.51 ± 0.23

6.42 ± 0.19

6.56 ± 0.21

UA

1.19 ± 0.73

1.33 ± 1.21

0.79 ± 0.29

0.76 ± 0.22

BUN

22.14 ± 1.68

21.60 ± 2.59

22.47 ± 1.89

22.76 ± 2.93

T-BIL

0.009 ± 0.013

0.006 ± 0.008

0.024 ± 0.017*

0.013 ± 0.014

IP

6.99 ± 0.82

6.98 ± 1.06

6.40 ± 0.51

6.59 ± 0.56

TG

140.20 ± 42.35

156.30 ± 49.69

161.40 ± 44.60

140.40 ± 47.28

CPK

554.10 ± 598.27

342.60 ± 267.05

269.10 ± 128.28

273.50 ± 130.37

Na

139.50 ± 1.18

142.40 ± 6.80

140.40 ± 0.70

141.20 ± 0.79

K

4.48 ± 0.98

4.36 ± 1.01

3.95 ± 0.78

3.99 ± 0.44

Cl

100.80 ± 1.40

102.30 ± 3.95

101.70 ± 0.67

101.40 ± 1.35

  1. Note. ALB(g/dL), Albumin; ALP(IU/L), Alkaline phosphatase; CA(mg/dL), Calcium; CHO(mg/dL), Total cholesterol; CRE(mg/dL), Creatinine; GGT(IU/L), Gamma glutamyl transpeptidase; GLU(mg/dL), Glucose; AST(IU/L), Aspartate aminotransferase; ALT(IU/L), Alanine aminotransferase; LDH(IU/L), Lactate dehydrogenase; MG(mg/dL), Magnesium; TP(g/dL), Total protein; UA(mg/dL), Uric acid; BUN(mg/dL), Blood urea nitrogen; T-BIL(mg/dL), Total bilirubin; IP(mg/dL), Inorganic phosphorus; TG(mg/dL), Triglyceride; CPK(U/L), Creatine phosphokinase; Na(mmol/L), Sodium; K(mmol/L), Potassium; Cl(mmol/L), Chloride.
  2. **Significant difference vs. control, p < 0.01
  3. *Significant difference vs. control, p < 0.05
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Particle and Fibre Toxicology

ISSN: 1743-8977

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