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Table 3 Serum values for male rats after 90-day oral administration of silver nanoparticles (mean ± S.D.)

From: Subchronic oral toxicity of silver nanoparticles

  Dose (mg/Kg)
  0 (n = 10) 30 (n = 10) 125 (n = 10) 500 (n = 10)
ALB 2.92 ± 0.26 2.82 ± 0.13 2.79 ± 0.10 2.86 ± 0.10
ALP 291.60 ± 35.40 279.50 ± 48.78 306.40 ± 35.16 343.80 ± 65.67
CA 10.93 ± 0.59 10.77 ± 0.67 10.49 ± 0.22 10.60 ± 0.24
CHO 88.50 ± 8.45 94.80 ± 7.54 98.30 ± 5.46** 106.00 ± 6.38**
CRE 0.91 ± 0.10 0.86 ± 0.11 0.85 ± 0.05 0.83 ± 0.15
GGT 0.40 ± 0.52 0.10 ± 0.32 0.40 ± 0.52 0.50 ± 0.53
GLU 168.20 ± 24.36 193.50 ± 42.15 165.40 ± 17.66 177.70 ± 20.89
AST 105.00 ± 27.01 97.10 ± 22.71 85.00 ± 12.35 98.20 ± 35.64
ALT 72.10 ± 5.17 77.20 ± 8.39 68.70 ± 4.64 71.40 ± 20.03
LDH 1230.80 ± 1351.96 784.80 ± 675.03 598.70 ± 351.37 644.20 ± 400.41
MG 2.27 ± 0.33 2.36 ± 0.62 2.06 ± 0.10 2.19 ± 0.09
TP 6.61 ± 0.21 6.51 ± 0.23 6.42 ± 0.19 6.56 ± 0.21
UA 1.19 ± 0.73 1.33 ± 1.21 0.79 ± 0.29 0.76 ± 0.22
BUN 22.14 ± 1.68 21.60 ± 2.59 22.47 ± 1.89 22.76 ± 2.93
T-BIL 0.009 ± 0.013 0.006 ± 0.008 0.024 ± 0.017* 0.013 ± 0.014
IP 6.99 ± 0.82 6.98 ± 1.06 6.40 ± 0.51 6.59 ± 0.56
TG 140.20 ± 42.35 156.30 ± 49.69 161.40 ± 44.60 140.40 ± 47.28
CPK 554.10 ± 598.27 342.60 ± 267.05 269.10 ± 128.28 273.50 ± 130.37
Na 139.50 ± 1.18 142.40 ± 6.80 140.40 ± 0.70 141.20 ± 0.79
K 4.48 ± 0.98 4.36 ± 1.01 3.95 ± 0.78 3.99 ± 0.44
Cl 100.80 ± 1.40 102.30 ± 3.95 101.70 ± 0.67 101.40 ± 1.35
  1. Note. ALB(g/dL), Albumin; ALP(IU/L), Alkaline phosphatase; CA(mg/dL), Calcium; CHO(mg/dL), Total cholesterol; CRE(mg/dL), Creatinine; GGT(IU/L), Gamma glutamyl transpeptidase; GLU(mg/dL), Glucose; AST(IU/L), Aspartate aminotransferase; ALT(IU/L), Alanine aminotransferase; LDH(IU/L), Lactate dehydrogenase; MG(mg/dL), Magnesium; TP(g/dL), Total protein; UA(mg/dL), Uric acid; BUN(mg/dL), Blood urea nitrogen; T-BIL(mg/dL), Total bilirubin; IP(mg/dL), Inorganic phosphorus; TG(mg/dL), Triglyceride; CPK(U/L), Creatine phosphokinase; Na(mmol/L), Sodium; K(mmol/L), Potassium; Cl(mmol/L), Chloride.
  2. **Significant difference vs. control, p < 0.01
  3. *Significant difference vs. control, p < 0.05