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Table 6 Hematological values for female rats after 90-day oral administration of silver nanoparticles (mean ± SD).

From: Subchronic oral toxicity of silver nanoparticles

  Dose (mg/Kg)
  0 (n = 8) 30 (n = 10) 125 (n = 10) 500 (n = 9)
WBC 5.46 ± 1.36 5.42 ± 0.81 5.11 ± 0.67 5.90 ± 0.97
RBC 8.46 ± 0.22 8.41 ± 0.34 8.19 ± 0.32 8.28 ± 0.24
Hb 16.24 ± 0.81 16.16 ± 0.75 15.82 ± 1.02 16.14 ± 0.85
HCT 34.45 ± 2.50 34.40 ± 1.80 34.33 ± 1.82 34.51 ± 2.13
MCV 40.70 ± 1.96 40.91 ± 1.62 41.95 ± 1.81 41.71 ± 2.45
MCH 19.20 ± 0.56 19.24 ± 0.81 19.34 ± 1.36 19.50 ± 0.96
MCHC 47.21 ± 1.80 47.02 ± 1.63 46.09 ± 1.96 46.84 ± 2.41
RDW 19.33 ± 2.44 19.18 ± 2.62 18.85 ± 2.55 19.04 ± 2.46
PLT 765.75 ± 110.30 718.30 ± 68.56 712.70 ± 55.93 688.89 ± 34.71
MPV 6.56 ± 0.71 6.74 ± 0.21 6.95 ± 0.28 6.70 ± 0.22
NEU 24.93 ± 2.88 27.37 ± 3.70 26.32 ± 6.70 24.06 ± 3.49
LYO 71.48 ± 3.83 68.32 ± 4.60 69.59 ± 7.53 71.22 ± 3.83
MONO 3.00 ± 1.17 3.85 ± 1.13 3.65 ± 0.79 4.54 ± 0.60*
EOS 0.42 ± 0.52 0.36 ± 0.17 0.39 ± 0.37 0.18 ± 0.15
BASO 0.17 ± 0.25 0.11 ± 0.09 0.15 ± 0.19 0.01 ± 0.02
  1. Note. WBC(K/μL), White blood cells; RBC(M/μL), Red blood cells; Hb(g/dL), Hemoglobin; HCT(%), Hematocrits; MCV(fl), Mean corpuscular volume; MCH(pg), Mean corpuscular hemoglobin; MCHC(g/dL), Mean corpuscular hemoglobin concentration; RDW(%), Red cell distribution width; PLT(K/μL), Platelets; MPV(fl), Mean platelet volume; NEU(%), Neutrophils; LYO(%), Lymphocytes; MONO(%), Monocytes; EOS(%), Eosinophils; BASO(%), Basophils. *Significant difference vs. control, p < 0.05