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Table 6 Hematological values for female rats after 90-day oral administration of silver nanoparticles (mean ± SD).

From: Subchronic oral toxicity of silver nanoparticles

 

Dose (mg/Kg)

 

0 (n = 8)

30 (n = 10)

125 (n = 10)

500 (n = 9)

WBC

5.46 ± 1.36

5.42 ± 0.81

5.11 ± 0.67

5.90 ± 0.97

RBC

8.46 ± 0.22

8.41 ± 0.34

8.19 ± 0.32

8.28 ± 0.24

Hb

16.24 ± 0.81

16.16 ± 0.75

15.82 ± 1.02

16.14 ± 0.85

HCT

34.45 ± 2.50

34.40 ± 1.80

34.33 ± 1.82

34.51 ± 2.13

MCV

40.70 ± 1.96

40.91 ± 1.62

41.95 ± 1.81

41.71 ± 2.45

MCH

19.20 ± 0.56

19.24 ± 0.81

19.34 ± 1.36

19.50 ± 0.96

MCHC

47.21 ± 1.80

47.02 ± 1.63

46.09 ± 1.96

46.84 ± 2.41

RDW

19.33 ± 2.44

19.18 ± 2.62

18.85 ± 2.55

19.04 ± 2.46

PLT

765.75 ± 110.30

718.30 ± 68.56

712.70 ± 55.93

688.89 ± 34.71

MPV

6.56 ± 0.71

6.74 ± 0.21

6.95 ± 0.28

6.70 ± 0.22

NEU

24.93 ± 2.88

27.37 ± 3.70

26.32 ± 6.70

24.06 ± 3.49

LYO

71.48 ± 3.83

68.32 ± 4.60

69.59 ± 7.53

71.22 ± 3.83

MONO

3.00 ± 1.17

3.85 ± 1.13

3.65 ± 0.79

4.54 ± 0.60*

EOS

0.42 ± 0.52

0.36 ± 0.17

0.39 ± 0.37

0.18 ± 0.15

BASO

0.17 ± 0.25

0.11 ± 0.09

0.15 ± 0.19

0.01 ± 0.02

  1. Note. WBC(K/μL), White blood cells; RBC(M/μL), Red blood cells; Hb(g/dL), Hemoglobin; HCT(%), Hematocrits; MCV(fl), Mean corpuscular volume; MCH(pg), Mean corpuscular hemoglobin; MCHC(g/dL), Mean corpuscular hemoglobin concentration; RDW(%), Red cell distribution width; PLT(K/μL), Platelets; MPV(fl), Mean platelet volume; NEU(%), Neutrophils; LYO(%), Lymphocytes; MONO(%), Monocytes; EOS(%), Eosinophils; BASO(%), Basophils. *Significant difference vs. control, p < 0.05
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Particle and Fibre Toxicology

ISSN: 1743-8977

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