Summary of different optical diagnostic techniques. (a) Schematic of free-space 360 degree projection FMT imaging system (reprinted with permission from ). (b) - (g) In this study, 2 × 105 cells (9L or HT1080) were stereotactically implanted into unilateral brain hemispheres of nude mice (reprinted with permission from ). Animals were then intravenously injected with the cathepsin-B imaging probe (2 nmol Cy 5.5 per animal). (b) and (c) Axial and sagittal MR slices of an animal implanted with a tumour, which is shown in green after gadolinium enhancement. (d), (e), and (f), Consecutive FMT slices obtained from top to bottom from the volume of interest shown on (c) by thin white horizontal lines. (f) Superposition of the MR axial slice passing through the tumour a onto the corresponding FMT slice c after appropriately translating the MR image to the actual dimensions of the FMT image. (h) - (k) In vivo FMT study of Alzheimer's disease progression using a fluorescent oxazine dye to quantify amyloid- [beta] plaques in a transgenic murine model (reprinted with permission from ).