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Table 1 EC50 and Emax values of concentration-response curves

From: Pulmonary exposure to carbon black nanoparticles and vascular effects

Exposure to carbon black EC50 (nM)    Emax (%)   
  ACh SNP PE ACh SNP PE
2 hours       
0.0 mg/kg 55.7 (24.5-127.1) 17.5 (14.4-21.2) 31.6 (24.7-40.3) 53.4 (43.9-62.9) 90.4 (87.5-93.3) 67.8 (64.3-71.3)
0.9 mg/kg 41.6 (22.0-78.7) 12.8 (10.0-16.4) 21.4 (18.2-25.2) 68.7 (60.2-77.2) 91.4 (87.7-95.0) 70.0 (67.6-72.4)
24 hours       
0.0 mg/kg 52.5 (33.5-82.3) 11.1 (8.0-15.5) 8.9 (7.6-10.4) 60.5 (55.1-65.9) 89.2 (84.9-93.5) 73.1 (71.0-75.2)
0.05 mg/kg 37.1 (20.9-65.8) 7.7 (5.7-10.3) 5.5 (4.3-7.0)* 53.6 (47.7-59.5) 93.9 (90.1-97.6) 73.4 (70.2-76.6)
0.5 mg/kg 59.0 (37.3-93.4) 16.8 (13.1-21.4) 5.8 (5.2-6.5)* 58.2 (52.5-63.8) 89.5 (85.9-93.0) 72.0 (70.3-73.7)
0.9 mg/kg 71.3 (47.8-106.1) 15.7 (10.5-23.7) 13.8 (9.8-19.5) 57.8 (52.6-63.0) 81.9 (76.5-87.3) 69.2 (64.6-73.8)
2.7 mg/kg 68.4 (33.2-141.0) 15.1 (7.4-30.5) 13.1 (8.7-19.8) 52.2 (44.1-60.3) 83.9 (75.0-92.9) 70.4 (65.2-75.7)
24 + 2 hours       
2 × 0.0 mg/kg 57.4 (31.9-103.1) 12.6 (8.5-18.8) 13.6 (11.2-16.5) 63.9 (55.5-72.3) 90.1 (84.7-95.5) 75.9 (72.8-78.9)
2 × 0.5 mg/kg 65.8 (42.3-102.4) 14.3 (11.5-17.7) 17.0 (14.3-20.3) 41.3 (37.0-45.5)* 91.9 (88.8-95.1) 75.1 (72.4-77.8)
  1. The concentration-response curves were performed for acetylcholine (ACh), sodium nitroprusside (SNP), and phenylephrine (PE) on aorta from 11-13 weeks old female ApoE-/- mice exposed in vivo to 0.0 or 0.9 mg/kg carbon black i.t. 2 hours before sacrifice, to 0; 0.05; 0.5; 0.9 or 2.7 mg/kg carbon black i.t. 24 hours before sacrifice or twice to 0.0 or 0.5 mg/kg carbon black 24 + 2 hours before sacrifice. The data are expressed as means and 95% CI. The number of animals in each group varied. * denotes statistically significant effects on EC50 or Emax as compared to the effect in the control group (P < 0.05, ANOVA with unequal variance between groups).