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Table 11 Histopathologic observations for female rats.

From: Subchronic inhalation toxicity of gold nanoparticles

GROUP: Control Low Middle High
Number of Animals 10 10 10 10
      N % N % N % N %
  No microscopic findings 9/10 90 9/10 90 8/10 80 7/10 70
  Abnormality 1/10 10 1/10 10 2/10 20 3/10 30
   Inflammation Focal minimum 0/10 0 1/10 10 0/10 0 0/10 0
Liver     mild 1/10 10 0/10 0 0/10 0 0/10 0
  Sign Necrosis Focal minimum 0/10 0 0/10 0 1/10 10 1/10 10
   Vacuolization Hepatocellular minimum 0/10 0 0/10 0 1/10 10 2/10 20
     mild 0/10 0 0/10 0 0/10 0 1/10 10
  No microscopic findings 10/10 100 10/10 100 9/10 90 3/10 30
Lungs Abnormality** 0/10 0 0/10 0 1/10 10 7/10 70
  Sign Inflammation** Focal minimum 0/10 0 0/10 0 1/10 10 6/10 60
     mild 0/10 0 0/10 0 0/10 0 1/10 10
  1. **, p < 0.01, compared with control. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously