|
GROUP:
|
Control
|
Low
|
Middle
|
High
|
|---|
|
Number of Animals
|
10
|
10
|
10
|
10
|
| | | | | |
N
|
%
|
N
|
%
|
N
|
%
|
N
|
%
|
| |
No microscopic findings
|
9/10
|
90
|
9/10
|
90
|
8/10
|
80
|
7/10
|
70
|
| |
Abnormality
|
1/10
|
10
|
1/10
|
10
|
2/10
|
20
|
3/10
|
30
|
| | |
Inflammation
|
Focal
|
minimum
|
0/10
|
0
|
1/10
|
10
|
0/10
|
0
|
0/10
|
0
|
|
Liver
| | | |
mild
|
1/10
|
10
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
| |
Sign
|
Necrosis
|
Focal
|
minimum
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
1/10
|
10
|
| | |
Vacuolization
|
Hepatocellular
|
minimum
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
2/10
|
20
|
| | | | |
mild
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
| |
No microscopic findings
|
10/10
|
100
|
10/10
|
100
|
9/10
|
90
|
3/10
|
30
|
|
Lungs
|
Abnormality**
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
7/10
|
70
|
| |
Sign
|
Inflammation**
|
Focal
|
minimum
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
6/10
|
60
|
| | | | |
mild
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
- **, p < 0.01, compared with control. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously
