Subchronic inhalation toxicity of gold nanoparticles

Table 11 Histopathologic observations for female rats.

GROUP:					Control		Low		Middle		High
Number of Animals					10		10		10		10
					N	%	N	%	N	%	N	%
	No microscopic findings				9/10	90	9/10	90	8/10	80	7/10	70
	Abnormality				1/10	10	1/10	10	2/10	20	3/10	30
		Inflammation	Focal	minimum	0/10	0	1/10	10	0/10	0	0/10	0
Liver				mild	1/10	10	0/10	0	0/10	0	0/10	0
	Sign	Necrosis	Focal	minimum	0/10	0	0/10	0	1/10	10	1/10	10
		Vacuolization	Hepatocellular	minimum	0/10	0	0/10	0	1/10	10	2/10	20
				mild	0/10	0	0/10	0	0/10	0	1/10	10
	No microscopic findings				10/10	100	10/10	100	9/10	90	3/10	30
Lungs	Abnormality**				0/10	0	0/10	0	1/10	10	7/10	70
	Sign	Inflammation**	Focal	minimum	0/10	0	0/10	0	1/10	10	6/10	60
				mild	0/10	0	0/10	0	0/10	0	1/10	10

**, p < 0.01, compared with control. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously

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