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Figure 13 | Particle and Fibre Toxicology

Figure 13

From: Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Figure 13

Lysosomal destabilization by ZnONP in THP-1 cells. Differentiated THP-1 cells by PMA (10 ng/ml) were stained with acridine orange for 15 min and cells were treated with NP for 24 h. (A), vehicle control; (B) TiO2NP at 10 cm2/ml (36.4 μg/ml); (C) ZnONP at 10 cm2/ml (20.6 μg/ml). Acridine orange dye aggregates inside of lysosome which showing red fluorescence. ZnONP showed less signals compared to vehicle control or TiO2NP.

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