Figure 11
Correlation between specific surface area or effective surface area of nanomaterials administered and pulmonary outcomes in the lung. (A) Correlation between specific surface area of NM administered (as measured by BET) and pulmonary outcomes in the lung following exposure to Crocidolite Asbestos, CNF, or SWCNT on day 1 post exposure. Pearson's correlation coefficients were calculated for pairs of variables including NM dose (expressed as specific surface area of NM per mouse) and the relative values of the respective pulmonary outcomes: ♦ - NM dose, m2/mouse; ■- alveolar wall thickness, day 28 post exposure (r = 0.995, p > 0.05); ▲ - 4-HNE, day1 post exposure (r = 0.837, p > 0.05; × - PMN counts, day1 post exposure (r = 0.908, p > 0.05); ✱ - IL-6, day1 post exposure (r = 0.733, p > 0.05); • - BAL protein, day1 post exposure (r = 0.979, p > 0.05). (B) Correlation between effective surface area of NM administered and pulmonary outcomes. Pearson's correlation coefficients were calculated for pairs of variables including NM dose (expressed as effective surface area of NM per mouse) and the relative values of the respective pulmonary outcomes: ♦ - NM dose, m2/mouse; ■- alveolar wall thickness, day 28 post exposure (r = 0.963, p > 0.05); ▲ - 4-HNE, day1 post exposure (r = 0.974, p > 0.05; × - PMN counts, day1 post exposure (r = 0.997, p < 0.05); ✱ - IL-6, day1 post exposure (r = 0.905, p > 0.05); • - BAL protein, day1 post exposure (r = 0.997, p < 0.05).