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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

Figure 4

Bright-field microscope image of THP-1 cells treated with AgNWs. A) AgNW3 and B) AgNW5 were fully enclosed by the cell as indicated by the yellow circle. C) AgNW10 were mostly taken up, however a small number of fibres were not fully enclosed and fibre ends were protruding out of the cells as indicated by the red arrow. D) AgNW14 and C) AgNW28 caused frustrated phagocytosis. Red arrows indicate fibres partly taken up by THP-1 cells and the black arrow indicates sharing of a fibre between two adjacent cells. Scale bar = 20 μm.

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