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Table 4 Genes commonly affected by 24 h cristobalite exposure in NHBE and BEAS 2B cells

From: Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells

Gene Name (Abbreviation)

Fold Changea

Cell Type

(Cristobalite) b

NHBE

(75)

BEAS 2B

(75)

BEAS 2B

(150)

Up-regulated â–²

   

Interleukin 8 (IL8)

28.47

2.12

2.65

BCL2-related protein A1 (BCL2A1)

19.27

NC

3.08

Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)

17.11

2.23

2.95

GTP binding protein overexpressed in skeletal muscle (GEM)

12.92

NC

2.13

Inhibin, Beta A (INHBA)

10.25

2.24

3.62

Interleukin 24 (IL24)

7.62

3.88

8.54

Heat shock 70 kDa protein 1A (HSPA1A)

7.56

NC

2.34

Chemokine (C-X-C motif) ligand 3 (CXCL3)

7.42

NC

2.42

TNF receptor-associated factor 1 (TRAF1)

7.30

2.86

4.22

Radical S-adenosyl methionine domain containing 2 (RSAD2)

6.92

5.45

23.25

Early growth response 1 (EGR1)

6.72

2.65

4.63

Coiled-coil domain containing 85B (CCDC85B)

6.46

3.44

6.11

FOS-like antigen 1 (FOSL1)

5.80

2.47

3.18

Early growth response 3 (EGR3)

5.31

NC

2.65

Jun oncogene (JUN)

4.99

NC

2.00

Matrix metallopeptidase 1, interstitial collagenase (MMP1)

4.99

16.12

44.68

2'-5'-oligoadenylate synthetase-like (OASL)

4.20

NC

18.85

cAMP responsive element binding protein 5 (CREB5)

3.87

3.25

4.10

Transcribed locus, strongly similar to NP_000337.1 transcription factor SOX9 (SOX9)

3.84

NC

2.12

Interferon induced with helicase C domain 1(IFIH1)

3.79

NC

3.86

Heat shock 70 kDa protein 6 (HSP70B')

3.70

4.08

14.39

Kynureninase (L-kynurenine hydrolase) (KYNU)

3.66

NC

2.19

Prostaglandin-endoperoxide synthase 2 (PTGS2)

3.56

NC

2.54

Superoxide dismutase 2, mitochondrial (SOD2)

3.53

NC

2.86

Interleukin 1 receptor-like 1 (IL1RL1)

3.52

2.89

5.36

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

3.45

6.01

16.26

Interferon-induced protein 44 (IFI44)

3.36

7.51

19.90

Nuclear receptor subfamily 1, group D, member 1 (NR1D1)

3.24

3.01

4.72

Interferon stimulated exonuclease gene 20 kDa (ISG20)

3.21

NC

2.48

Plasminogen activator, urokinase receptor (PLAUR)

3.14

NC

2.35

Transmembrane protein 40 (TMEM40)

3.06

NC

4.15

Distal-less homeobox 2 (DLX2)

2.99

2.34

3.78

Niacin receptor 2 (NIACR2 OR GPR109B)

2.87

3.14

NC

Human 28S ribosomal RNA gene, complete cds. (RNA28S1)

2.86

NC

2.21

Histone deacetylase 9 (HDAC9)

2.84

3.24

NC

2'-5'-oligoadenylate synthetase 1, 40/46 kDa (OAS1)

2.83

NC

20.53

Nuclear receptor subfamily 4, group A, member 3 (NR4A3)

2.79

2.58

3.49

Oxidative stress induced growth inhibitor 1 (OSGIN1)

2.79

NC

2.48

Smoothelin (SMTN)

2.74

2.38

2.72

Heme oxygenase (decycling) 1 (HMOX1)

2.69

NC

2.57

Basic helix-loop-helix family, member e41 (BHLHE41)

2.64

NC

2.34

ADAM metallopeptidase domain 8 (ADAM8)

2.62

NC

2.08

Crystallin, alpha B (CRYAB)

2.58

2.26

2.67

Colony stimulating factor 2 (granulocyte-macrophage) (CSF2)

2.53

4.20

7.37

Calcium binding tyrosine-(Y)-phosphorylation regulated (CABYR)

2.51

NC

2.19

Chromosome 1 open reading frame 38 (C1orf38)

2.44

NC

3.04

2'-5'-oligoadenylate synthetase 3, 100 kDa (OAS3)

2.29

2.41

3.84

Sprouty homolog 4 (Drosophila) (SPRY4)

2.26

2.98

4.64

Dual specificity phosphatase 5 (DUSP5)

2.23

2.02

2.61

Ring finger protein 39 (RNF39)

2.22

2.47

3.65

Leukemia inhibitor factor (Cholinergic differentiation factor) (LIF)

2.21

2.96

4.73

Sphingosine kinase 1 (SPHK1)

2.11

3.20

4.88

Interleukin 6 (Interferon, beta 2) (IL6)

2.10

2.12

2.59

Interleukin 1, alpha (IL1A)

2.09

3.97

6.17

FBJ murine osteosarcoma viral oncogene homolog B (FOSB)

2.07

3.65

6.37

Serpin peptidase inhibitor, clade B (ovalbumin), member 2 (PAI2)

2.04

2.16

4.33

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60)

2.02

2.26

5.01

Down-regulated â–¼

   

Sulfatase 1 (SULF1)

3.59

2.01

2.10

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A)

3.52

2.85

3.75

Chromosome 5 open reading frame 13 (C5orf13)

2.05

NC

2.21

  1. Sixty genes (57 up-regulated and 3 down-regulated) found commonly altered by exposure to cristobalite silica in NHBE cells and BEAS 2B cells from microarray analysis. Genes are listed in descending order of fold-change compared to controls seen in NHBE cells.
  2. a Fold change (mRNA) expression (p < 0.05) cut-off ≥ 2.0-fold compared to controls (n = 3)
  3. b Cristobalite silica particle concentrations: (× 106μm2/cm2)
  4. NC = No Change
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Particle and Fibre Toxicology

ISSN: 1743-8977

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