Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats

Table 1 Predicted activation of molecules based on microarray analysis

Molecule type	4 h	24 h
Complex	PDGF BB; NFkB; IL12
Cytokine	IFNG; IL6; TNF; TNFSF12; IL1B; TNFSF11; IL17A; IL13; IL2; Cxcl12; CSF2; C5; (IL1RN)	IL2
Enzyme	TGM2; CD44; PTGS2; CD38; NOS2; (TAB1)	TGM2
G-Protein coupled receptor	CCR2
Group	Pkc(s); Ifnar; P38 MAPK; Ifn; Akt
Growth factor	KITLG; FGF2
Kinase	IKBKB; CHUK; PRKCD
Transcription regulator	IRF7; CEBPA; STAT1; EGR1; STAT3; IRF1; NFKBIA; IRF5; CEBPB; IRF3; MTPN; (MYC); (TRIM24)	TP53
Transmembrane receptor	TLR3; TLR4; IFNAR1

The identified molecules were derived from IPA upstream regulator analysis. All molecules had z-scores greater than 2.0 for a predicted activated upstream regulator and less than −2.0 for a predicted inhibited upstream regulator. Inhibited upstream regulators are shown in parentheses.

ISSN: 1743-8977