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Table 4 Bronchoalveolar lavage analysis at 1 day after intratracheal instillation of BaSO 4 NPs

From: Biokinetics and effects of barium sulfate nanoparticles

Dose Control 1 mg/kg 2 mg/kg 5 mg/kg
BaSO4 lung burden (mg) 0 0.28 ± 0.004 0.56 ± 0.004 1.4 ± 0.004
Total Cells (million) 8.31 ± 1.01 12.59 ± 1.71 14.26 ± 0.74* 16.76 ± 1.15*
Macrophage (million) 8.31 ± 1.01 12.28 ± 1.62 11.41 ± 0.67 10.31 ± 1.40
Neutrophils (million 0.001 ± 0.00 0.29 ± 0.10 2.85 ± 0.29* 6.45 ± 1.09*
LDH (mU/ml) 38.10 ± 0.30 57.23 ± 4.98 171.52 ± 33.05 167.68 ± 18.53*
MPO (mU/ml) 0.94 ± 0.07 0.80 ± 0.21 26.48 ± 8.50 34.95 ± 8.82
Albumin (μg/ml) 3.28 ± 1.39 6.12 ± 0.38* 11.88 ± 1.20* 14.53 ± 1.12*
Hemoglobin (μg) 9.44 ± 1.39 16.56 ± 0.89* 24.79 ± 2.78* 37.24 ± 2.64*
  1. Data are mean ± SE, n = 4-5/group.
  2. *p <0.05, BaSO4 versus 0 mg/kg (Control, equivalent volume of distilled water).