Table 4 Bronchoalveolar lavage analysis at 1 day after intratracheal instillation of BaSO ₄ NPs

BaSO₄ lung burden (mg)

0

0.28 ± 0.004

0.56 ± 0.004

1.4 ± 0.004

Total Cells (million)

8.31 ± 1.01

12.59 ± 1.71

14.26 ± 0.74*

16.76 ± 1.15*

Macrophage (million)

8.31 ± 1.01

12.28 ± 1.62

11.41 ± 0.67

10.31 ± 1.40

Neutrophils (million

0.001 ± 0.00

0.29 ± 0.10

2.85 ± 0.29*

6.45 ± 1.09*

LDH (mU/ml)

38.10 ± 0.30

57.23 ± 4.98

171.52 ± 33.05

167.68 ± 18.53*

MPO (mU/ml)

0.94 ± 0.07

0.80 ± 0.21

26.48 ± 8.50

34.95 ± 8.82

Albumin (μg/ml)

3.28 ± 1.39

6.12 ± 0.38*

11.88 ± 1.20*

14.53 ± 1.12*

Hemoglobin (μg)

9.44 ± 1.39

16.56 ± 0.89*

24.79 ± 2.78*

37.24 ± 2.64*